Notch signaling is evolutionarily conserved and operates in many cell types and at various
stages during development. Notch signaling must therefore be able to generate appropriate …

Notch signaling is involved in cell fate determination and deregulated in human solid
tumors. Hypoxia is an important feature in many solid tumors, which activates hypoxia …

Unlike solid organs, human airway epithelia derive their oxygen from inspired air rather than
the vasculature. Many pulmonary diseases are associated with intraluminal airway …

Background Wnt proteins are important for developmental processes and certain diseases.
WNT5A is a non-canonical Wnt protein that previously has been shown to play a role in the …

Notch signaling is an evolutionarily conserved pathway involved in cell fate control during
development, stem cell self-renewal, and postnatal tissue differentiation. Roles for Notch in …

Pogo transposable element derived with ZNF domain (POGZ) has been identified as one of
the most recurrently de novo mutated genes in patients with neurodevelopmental disorders …

Abstract γ‐Secretase inhibitors (GSI s) are being actively repurposed as cancer therapeutics
based on the premise that inhibition of NOTCH 1 signaling in select cancers is therapeutic …

Biomarkers in breast cancer to monitor minimal residual disease have remained elusive. We
hypothesized that genomic analysis of circulating free DNA (cfDNA) isolated from plasma …

Scleroderma (SSc) is a complex disease that involves activation of the immune system,
vascular complications, and tissue fibrosis. The histone methyltransferase enhancer of zeste …

Gastric cancer (GC) is commonly treated by chemotherapy using 5-fluorouracil (5-FU)
derivatives and platinum combination, but predictive biomarker remains lacking. We develop …