Summary p53-binding protein 1 (53BP1) regulates both the DNA damage response and p53
signaling. Although 53BP1's function is well established in DNA double-strand break repair …

Lung cancer is one of the most common malignancies worldwide. The present study aimed
to investigate specific genotypes of different subtypes or stages of lung cancer through gene …

Glioblastomas are universally fatal cancers and contain self-renewing glioblastoma stem
cells (GSCs) that initiate tumors. Traditional anticancer drug discovery based on in vitro …

Background Diapause is a developmental alternative to direct ontogeny in many
invertebrates. Its primary adaptive meaning is to secure survival over unfavourable seasons …

Diapause is an endogenously regulated dormant state that allows insects and other animals
to survive seasons of inimical conditions. Diapause is characterized by altered gene …

Epigenetic mechanisms, including histone modifications, have emerged as important factors
influencing cell fate determination. The functional role of H3K4 methylation, however …

DPY30, a core subunit of the SET1/MLL histone H3K4 methyltransferase complexes, plays
an important role in diverse biological functions through the epigenetic regulation of gene …

Telomeres are nucleoprotein structures at the ends of linear chromosomes. In humans, they
consist of TTAGGG repeats, which are bound by dedicated proteins such as the shelterin …

DPY-30 is a subunit of mammalian COMPASS-like complexes (complex of proteins
associated with Set1) and regulates global histone H3 Lys-4 trimethylation. Here we report …

Human induced pluripotent stem cells (iPSCs) require high levels of methionine (Met). Met
deprivation results in a rapid decrease in intracellular S-adenosyl-methionine (SAM) …