Abstract The legacy of Gilbert Newton Lewis (1875–1946) pervades the lexicon of chemical
bonding and reactivity. The power of his concept of donor–acceptor bonding is evident in the …

Chirality is a universal phenomenon in molecular and biological systems, denoting an
asymmetric configurational property where an object cannot be superimposed onto its mirror …

Chiral tertiary alcohols and R-tertiary amines are important building blocks of naturally
occurring and artificial biologically active molecules. Although there are catalytic asymmetric …

Transforming amino acids into novel catalysts and ligands is a remarkable subset of new
catalyst development in order to imitate enzymatic efficiencies. Their ability to perform a …

Catalytic asymmetric cyanations of prochiral unsaturated compounds affording the
corresponding nitrile products in high enantiomeric excess (≥ 90% in general) are …

There is a growing need in organic synthesis for efficient methodologies for the asymmetric
synthesis of quaternary carbon centres. One of the most attractive and straightforward …

The addition of cyanide to a carbonyl compound to form a cyanohydrin is one of the
fundamental carbon-carbon bond forming reactions in organic chemistry1 and has …

Enantioselective catalytic formation of tertiary stereogenic centers has nowadays reached
an impressive level of maturity, as is reflected in the large variety of available methods that …

Trimethylsilyl nucleophiles (Me3SiNu), with silicon atoms attached to carbon, nitrogen,
oxygen, or sulfur atoms, have long been recognized as effective alternatives for proton …

Phosphoranes 2 are identified as a class of effective Lewis bases to activate chiral (salen)
AlCl complex 1 to enhance its electrophilicity. Accordingly, a three-component catalyst …