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Recent advance in the development of N-heterocyclic derivatives as anti-SARS-CoV-2 inhibitors: A review
The pandemic caused by COVID-19 hinders everything on earth, including physical and
mental health, daily life and the global economy. Currently, there are no defined drugs and …
mental health, daily life and the global economy. Currently, there are no defined drugs and …
Oxadiazole: A highly versatile scaffold in drug discovery
N Desai, J Monapara, A Jethawa… - Archiv der …, 2022 - Wiley Online Library
As a pharmacologically important heterocycle, oxadiazole paved the way to combat the
problem associated with the confluence of many commercially available drugs with different …
problem associated with the confluence of many commercially available drugs with different …
Synthesis of new carboxylates and sulfonates containing thiazolidin-4-one ring and evaluation of inhibitory properties against some metabolic enzymes
A series of thizaolidin-4-one derivatives (3a-o) was synthesized with excellent yield (94–
97%) and the structures of the compounds were characterized with Fourier-transform …
97%) and the structures of the compounds were characterized with Fourier-transform …
Novel antimicrobial 8-hydroxyquinoline-based agents: Current development, structure–activity relationships, and perspectives
AR Joaquim, MP Gionbelli, G Gosmann… - Journal of Medicinal …, 2021 - ACS Publications
The search for new antimicrobials is imperative due to the emergent resistance of new
microorganism strains. In this context, revisiting known classes like 8-hydroxyquinolines …
microorganism strains. In this context, revisiting known classes like 8-hydroxyquinolines …
Molecular hybrids integrated with imidazole and hydrazone structural motifs: Design, synthesis, biological evaluation, and molecular docking studies
In the present work, a series of compounds containing imidazole and hydrazone structural
frameworks were synthesized and characterized using various spectral techniques …
frameworks were synthesized and characterized using various spectral techniques …
Quinoline thiourea-based zinc ionophores with antibacterial activity
The increasing resistance of bacteria to commercially available antibiotics threatens patient
safety in healthcare settings. Perturbation of ion homeostasis has emerged as a potential …
safety in healthcare settings. Perturbation of ion homeostasis has emerged as a potential …
Current progress toward synthetic routes and medicinal significance of quinoline
Quinoline motifs are essential in several pharmacological active heterocyclic compounds
due to their various applications in medicinal and industrial chemistry. Furthermore, there …
due to their various applications in medicinal and industrial chemistry. Furthermore, there …
[HTML][HTML] Anticancer activities of tetra-, penta-, and hexacyclic phenothiazines modified with quinoline moiety.
M Jeleń, B Morak-Młodawska, R Korlacki - Journal of Molecular Structure, 2023 - Elsevier
The quinoline molecule is a chemical motif showing a highly promising pharmacological
potential. Its numerous derivatives introduced into medicine revolutionized in the treatment …
potential. Its numerous derivatives introduced into medicine revolutionized in the treatment …
Quinoline‐based thiazolidinone derivatives as potent cytotoxic and apoptosis‐inducing agents through EGFR inhibition
Quinoline‐based thiazolidinone heterocycles exhibited potent activity in the field of cancer
therapy. Hence, ten quinoline‐based thiazolidinone derivatives were evaluated for their …
therapy. Hence, ten quinoline‐based thiazolidinone derivatives were evaluated for their …
[HTML][HTML] Recent advances in the synthesis and biological activity of 8-hydroxyquinolines
Compounds containing the 8-hydroxyquinoline (8-HQ) 1 nucleus exhibit a wide range of
biological activities, including antimicrobial, anticancer, and antifungal effects. The chemistry …
biological activities, including antimicrobial, anticancer, and antifungal effects. The chemistry …