Recent advance in the development of N-heterocyclic derivatives as anti-SARS-CoV-2 inhibitors: A review

W Ettahiri, M Adardour, S Alaoui, AEA Allah… - Phytochemistry …, 2024 - Elsevier
The pandemic caused by COVID-19 hinders everything on earth, including physical and
mental health, daily life and the global economy. Currently, there are no defined drugs and …

Oxadiazole: A highly versatile scaffold in drug discovery

N Desai, J Monapara, A Jethawa… - Archiv der …, 2022 - Wiley Online Library
As a pharmacologically important heterocycle, oxadiazole paved the way to combat the
problem associated with the confluence of many commercially available drugs with different …

Synthesis of new carboxylates and sulfonates containing thiazolidin-4-one ring and evaluation of inhibitory properties against some metabolic enzymes

FS Tokalı, P Taslimi, B Tüzün, A Karakuş… - Journal of the Iranian …, 2023 - Springer
A series of thizaolidin-4-one derivatives (3a-o) was synthesized with excellent yield (94–
97%) and the structures of the compounds were characterized with Fourier-transform …

Novel antimicrobial 8-hydroxyquinoline-based agents: Current development, structure–activity relationships, and perspectives

AR Joaquim, MP Gionbelli, G Gosmann… - Journal of Medicinal …, 2021 - ACS Publications
The search for new antimicrobials is imperative due to the emergent resistance of new
microorganism strains. In this context, revisiting known classes like 8-hydroxyquinolines …

Molecular hybrids integrated with imidazole and hydrazone structural motifs: Design, synthesis, biological evaluation, and molecular docking studies

M Tapera, H Kekeçmuhammed, E Sarıpınar… - Journal of Molecular …, 2023 - Elsevier
In the present work, a series of compounds containing imidazole and hydrazone structural
frameworks were synthesized and characterized using various spectral techniques …

Quinoline thiourea-based zinc ionophores with antibacterial activity

S Dey, A Patel, N Haloi, S Srimayee… - Journal of Medicinal …, 2023 - ACS Publications
The increasing resistance of bacteria to commercially available antibiotics threatens patient
safety in healthcare settings. Perturbation of ion homeostasis has emerged as a potential …

Current progress toward synthetic routes and medicinal significance of quinoline

WS Shehab, MMK Amer, DA Elsayed, KK Yadav… - Medicinal Chemistry …, 2023 - Springer
Quinoline motifs are essential in several pharmacological active heterocyclic compounds
due to their various applications in medicinal and industrial chemistry. Furthermore, there …

[HTML][HTML] Anticancer activities of tetra-, penta-, and hexacyclic phenothiazines modified with quinoline moiety.

M Jeleń, B Morak-Młodawska, R Korlacki - Journal of Molecular Structure, 2023 - Elsevier
The quinoline molecule is a chemical motif showing a highly promising pharmacological
potential. Its numerous derivatives introduced into medicine revolutionized in the treatment …

Quinoline‐based thiazolidinone derivatives as potent cytotoxic and apoptosis‐inducing agents through EGFR inhibition

MS Nafie, SM Kishk, S Mahgoub… - Chemical Biology & …, 2022 - Wiley Online Library
Quinoline‐based thiazolidinone heterocycles exhibited potent activity in the field of cancer
therapy. Hence, ten quinoline‐based thiazolidinone derivatives were evaluated for their …

[HTML][HTML] Recent advances in the synthesis and biological activity of 8-hydroxyquinolines

HA Saadeh, KA Sweidan, MS Mubarak - Molecules, 2020 - mdpi.com
Compounds containing the 8-hydroxyquinoline (8-HQ) 1 nucleus exhibit a wide range of
biological activities, including antimicrobial, anticancer, and antifungal effects. The chemistry …