Advances in biosynthesis, regulation, and metabolic engineering of plant specialized terpenoids

DA Nagegowda, P Gupta - Plant Science, 2020 - Elsevier
Plant specialized terpenoids are natural products that have no obvious role in growth and
development, but play many important functional roles to improve the plant's overall fitness …

Environmental and genetic factors involved in plant protection-associated secondary metabolite biosynthesis pathways

X Zhan, Z Chen, R Chen, C Shen - Frontiers in Plant Science, 2022 - frontiersin.org
Plant specialized metabolites (PSMs) play essential roles in the adaptation to harsh
environments and function in plant defense responses. PSMs act as key components of …

A microbial supply chain for production of the anti-cancer drug vinblastine

J Zhang, LG Hansen, O Gudich, K Viehrig… - Nature, 2022 - nature.com
Monoterpene indole alkaloids (MIAs) are a diverse family of complex plant secondary
metabolites with many medicinal properties, including the essential anti-cancer therapeutics …

Single-cell multi-omics in the medicinal plant Catharanthus roseus

C Li, JC Wood, AH Vu, JP Hamilton… - Nature Chemical …, 2023 - nature.com
Advances in omics technologies now permit the generation of highly contiguous genome
assemblies, detection of transcripts and metabolites at the level of single cells and high …

The seco-iridoid pathway from Catharanthus roseus

K Miettinen, L Dong, N Navrot, T Schneider… - Nature …, 2014 - nature.com
The (seco) iridoids and their derivatives, the monoterpenoid indole alkaloids (MIAs), form
two large families of plant-derived bioactive compounds with a wide spectrum of high-value …

Stimulating photosynthetic processes increases productivity and water-use efficiency in the field

PE López-Calcagno, KL Brown, AJ Simkin, SJ Fisk… - Nature Plants, 2020 - nature.com
Previous studies have demonstrated that the independent stimulation of either electron
transport or RuBP regeneration can increase the rate of photosynthetic carbon assimilation …

Transcription factor CitERF71 activates the terpene synthase gene CitTPS16 involved in the synthesis of E-geraniol in sweet orange fruit

X Li, Y Xu, S Shen, X Yin, H Klee… - Journal of …, 2017 - academic.oup.com
The unique flavor of Citrus fruit depends on complex combinations of soluble sugars,
organic acids, and volatile compounds. The monoterpene E-geraniol is an important volatile …

Manipulation of GES and ERG20 for geraniol overproduction in Saccharomyces cerevisiae

GZ Jiang, MD Yao, Y Wang, L Zhou, TQ Song, H Liu… - Metabolic …, 2017 - Elsevier
Manipulation of monoterpene synthases to maximize flux towards targeted products from
GPP (geranyl diphosphate) is the main challenge for heterologous monoterpene …

Biosynthesis of monoterpenoid and sesquiterpenoid as natural flavors and fragrances

H Jiang, X Wang - Biotechnology Advances, 2023 - Elsevier
Terpenoids are a large class of plant-derived compounds, that constitute the main
components of essential oils and are widely used as natural flavors and fragrances. The …

The bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus

A Van Moerkercke, P Steensma… - Proceedings of the …, 2015 - National Acad Sciences
Plants make specialized bioactive metabolites to defend themselves against attackers. The
conserved control mechanisms are based on transcriptional activation of the respective …