Mechanisms, pathophysiology, and management of obesity

SB Heymsfield, TA Wadden - New England Journal of Medicine, 2017 - Mass Medical Soc
Obesity is prevalent in the US population and contributes significantly to morbidity and
mortality. Treatments include behavioral therapy, pharmacotherapy, and bariatric surgery …

Energy balance and obesity: what are the main drivers?

I Romieu, L Dossus, S Barquera, HM Blottière… - Cancer causes & …, 2017 - Springer
Purpose The aim of this paper is to review the evidence of the association between energy
balance and obesity. Methods In December 2015, the International Agency for Research on …

Principles of DNA methylation and their implications for biology and medicine

Y Dor, H Cedar - The Lancet, 2018 - thelancet.com
DNA methylation represents an annotation system for marking the genetic text, thus
providing instruction as to how and when to read the information and control transcription …

The science of food security

MB Cole, MA Augustin, MJ Robertson… - npj Science of Food, 2018 - nature.com
We need to feed an estimated population in excess of 9 billion by 2050 with diminishing
natural resources, whilst ensuring the health of people and the planet. Herein we connect …

Early beta cell dysfunction vs insulin hypersecretion as the primary event in the pathogenesis of dysglycaemia

N Esser, KM Utzschneider, SE Kahn - Diabetologia, 2020 - Springer
Obesity and insulin resistance are associated with the development of type 2 diabetes. It is
well accepted that beta cell dysfunction is required for hyperglycaemia to occur. The …

Extracellular matrix remodeling of adipose tissue in obesity and metabolic diseases

FJ Ruiz-Ojeda, A Méndez-Gutiérrez… - International journal of …, 2019 - mdpi.com
The extracellular matrix (ECM) is a network of different proteins and proteoglycans that
controls differentiation, migration, repair, survival, and development, and it seems that its …

DNA methylation markers in obesity, metabolic syndrome, and weight loss

M Samblas, FI Milagro, A Martínez - Epigenetics, 2019 - Taylor & Francis
The fact that not all individuals exposed to the same environmental risk factors develop
obesity supports the hypothesis of the existence of underlying genetic and epigenetic …

Nutrigenetics, epigenetics and gestational diabetes: consequences in mother and child

M Franzago, F Fraticelli, L Stuppia, E Vitacolonna - Epigenetics, 2019 - Taylor & Francis
ABSTRACT Gestational Diabetes Mellitus (GDM) is the most common metabolic condition
during pregnancy and may result in short-and long-term complications for both mother and …

Protective Effects of (E)-β-Caryophyllene (BCP) in Chronic Inflammation

R Scandiffio, F Geddo, E Cottone, G Querio… - Nutrients, 2020 - mdpi.com
(E)-β-caryophyllene (BCP) is a bicyclic sesquiterpene widely distributed in the plant
kingdom, where it contributes a unique aroma to essential oils and has a pivotal role in the …

Cardiometabolic risk in obese children

ST Chung, AU Onuzuruike… - Annals of the New York …, 2018 - Wiley Online Library
Obesity in childhood remains a significant and prevalent public health concern. Excess
adiposity in youth is a marker of increased cardiometabolic risk (CMR) in adolescents and …