DNA methylation is an important regulator of gene transcription, and its role in
carcinogenesis has been a topic of considerable interest in the last few years. Alterations in …

Epigenetic alterations, such as abnormal DNA-methylation patterns, are associated with
many human tumour types. New techniques have been developed to perform genome-wide …

Gastric cancer is the leading cause of cancer-related mortality across the world, with poor
prognosis and a median overall survival of≤ 12 months for advanced stage gastric cancer …

Mutations of the APC tumor suppressor gene are found frequently in gastric adenomas, but
only rarely in gastric cancers; this is clearly different from the similar frequencies of APC …

The development and progression of gastric cancer involves a number of genetic and
epigenetic alterations of tumor suppressor and tumor-related genes. The majority of …

Epigenetic alterations, represented by aberrant DNA methylation, are deeply involved in
human cancers. In gastric cancers, tumor-suppressor genes are inactivated more frequently …

Aberrant hypermethylation of promoter CpG islands is an important mechanism for the
inactivation of tumor suppressor genes. CpG island hypermethylation occurs in relation to …

Background Endoscopic resection (ER) has been widely accepted in Japan as a less
invasive treatment for early gastric cancer, but the incidence of subsequent metachronous …

BACKGROUND & AIMS: By using methylation-sensitive representational difference
analysis, we identified protocadherin 10 (PCDH10), a gene that encodes a protocadherin …

Gastric cancer is a complex heterogeneous disease which is the fourth prevalent
malignancy worldwide. Although, several diagnosis and treatment are available for the …