Megakaryocytes are hematopoietic cells, which are responsible for the production of blood
platelets. The traditional view of megakaryopoiesis describes the cellular journey from …

Regenerative medicine, the most recent and emerging branch of medical science, deals
with functional restoration of tissues or organs for the patient suffering from severe injuries or …

A lack of models that recapitulate the complexity of human bone marrow has hampered
mechanistic studies of normal and malignant hematopoiesis and the validation of novel …

The ex vivo generation of platelets from human-induced pluripotent cells (hiPSCs) is
expected to compensate donor-dependent transfusion systems. However, manufacturing the …

The production of megakaryocytes (MKs)—the precursors of blood platelets—from human
pluripotent stem cells (hPSCs) offers exciting clinical opportunities for transfusion medicine …

A significant challenge in the current orthopedics is the development of suitable
osteobiologic materials that can replace the conventional allografts, autografts, and …

Platelets, small hemostatic blood cells, are derived from megakaryocytes. Both bone marrow
and lung are principal sites of thrombopoiesis although underlying mechanisms remain …

The bone marrow niche consists of stem and progenitor cells destined to become mature
cells such as haematopoietic elements, osteoblasts or adipocytes. Marrow cells, influenced …

Hematopoietic stem cells (HSCs) are fundamental to the generation of the body's blood and
immune cells. They reside primarily within the bone marrow (BM) niche microenvironment …

Platelets are anucleate cytoplasmic discs derived from megakaryocytes that circulate in the
blood and have major roles in hemostasis, thrombosis, inflammation, and vascular biology …