Advances in develo** novel therapeutic strategies for Alzheimer's disease
J Cao, J Hou, J **, D Cai - Molecular neurodegeneration, 2018 - Springer
Abstract Alzheimer's Disease (AD), the most prevalent neurodegenerative disease of aging,
affects one in eight older Americans. Nearly all drug treatments tested for AD today have …
affects one in eight older Americans. Nearly all drug treatments tested for AD today have …
New approaches for the treatment of Alzheimer's disease
Alzheimer's disease (AD) is the most prevalent chronic neurodegenerative disease. Current
approved therapies are symptomatic treatments having some effect on cognitive function …
approved therapies are symptomatic treatments having some effect on cognitive function …
Innovative therapy for Alzheimer's disease-with focus on biodelivery of NGF
Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with
abnormal protein modification, inflammation and memory impairment. Aggregated amyloid …
abnormal protein modification, inflammation and memory impairment. Aggregated amyloid …
Metabolic homeostasis via BDNF and its receptors
Metabolic disorders result from dysregulation of central nervous system and peripheral
metabolic energy homeostatic pathways. To maintain normal energy balance, neural circuits …
metabolic energy homeostatic pathways. To maintain normal energy balance, neural circuits …
Nerve growth factor receptor (Ngfr) induces neurogenic plasticity by suppressing reactive astroglial Lcn2/Slc22a17 signaling in Alzheimer's disease
Neurogenesis, crucial for brain resilience, is reduced in Alzheimer's disease (AD) that
induces astroglial reactivity at the expense of the pro-neurogenic potential, and restoring …
induces astroglial reactivity at the expense of the pro-neurogenic potential, and restoring …
Translating the biology of aging into novel therapeutics for Alzheimer disease
Y Hara, N McKeehan, HM Fillit - Neurology, 2019 - AAN Enterprises
Aging is the leading risk factor for most chronic illnesses of old age, including Alzheimer
disease (AD), a progressive neurodegenerative disease with currently no therapies that …
disease (AD), a progressive neurodegenerative disease with currently no therapies that …
Neuronally differentiated macula densa cells regulate tissue remodeling and regeneration in the kidney
Tissue regeneration is limited in several organs, including the kidney, contributing to the
high prevalence of kidney disease globally. However, evolutionary and physiological …
high prevalence of kidney disease globally. However, evolutionary and physiological …
In vivo functions of p75NTR: Challenges and opportunities for an emerging therapeutic target
The p75 neurotrophin receptor (p75 NTR) functions at the molecular nexus of cell death,
survival, and differentiation. In addition to its contribution to neurodegenerative diseases and …
survival, and differentiation. In addition to its contribution to neurodegenerative diseases and …
The Nerve Growth Factor Receptor (NGFR/p75NTR): A Major Player in Alzheimer's Disease
Alzheimer's disease (AD) represents the most prevalent type of dementia in elderly people,
primarily characterized by brain accumulation of beta-amyloid (Aβ) peptides, derived from …
primarily characterized by brain accumulation of beta-amyloid (Aβ) peptides, derived from …
Precision pharmacology for Alzheimer's disease
The complex multifactorial nature of polygenic Alzheimer's disease (AD) presents significant
challenges for drug development. AD pathophysiology is progressing in a non-linear …
challenges for drug development. AD pathophysiology is progressing in a non-linear …