Increasing evidence from epidemiological, clinical and experimental studies indicate that
age-related cerebromicrovascular dysfunction and microcirculatory damage play critical …

The brain possesses two intricate mechanisms that fulfill its continuous metabolic needs:
cerebral autoregulation, which ensures constant cerebral blood flow over a wide range of …

Hyperemia in response to neural activity is essential for brain health. A hyperemic response
delivers O2 and nutrients, clears metabolic waste, and concomitantly exposes …

Hypertension in the elderly substantially contributes to cerebromicrovascular damage and
promotes the development of vascular cognitive impairment. Despite the importance of the …

Traumatic brain injury (TBI) is a major health problem worldwide. In addition to its high
mortality (35–40%), survivors are left with cognitive, behavioral, and communicative …

Regulation of cerebral blood flow (CBF) is the result of multilevel mechanisms to maintain
the appropriate blood supply to the brain while having to comply with the limited space …

Aging impairs autoregulatory protection in the brain, exacerbating hypertension-induced
cerebromicrovascular injury, neuroinflammation, and development of vascular cognitive …

Cerebrovascular lesions, mainly germinal matrix hemorrhage and ischemic injury to the
periventricular white matter, are major causes of adverse neurodevelopmental outcome in …

Basal and activity-dependent cerebral blood flow changes are coordinated by the action of
critical processes, including cerebral autoregulation, endothelial-mediated signaling, and …

Cognitive performances are tightly associated with the maximal aerobic exercise capacity,
both of which decline with age. The benefits on mental health of regular exercise, which …