The transcription factor p53 is an important regulator of a multitude of cellular processes. In
the presence of genotoxic stress, p53 is activated to facilitate DNA repair, cell cycle arrest …

Breast cancer (BC) is the second most fatal disease and is the prime cause of cancer allied
female deaths. BC is caused by aberrant tumor suppressor genes and oncogenes regulated …

Conventional chemotherapy, one of the most widely used cancer treatment methods, has
serious side effects, and usually results in cancer treatment failure. Drug resistance is one of …

Heavy metals are naturally occurring components of the Earth's crust and persistent
environmental pollutants. Human exposure to heavy metals occurs via various pathways …

Telomeres protect the ends of chromosomes but shorten following cell division in the
absence of telomerase activity. When telomeres become critically short or damaged, a DNA …

Triple negative breast cancer (TNBC) is an aggressive disease which currently has no
effective therapeutic targets and prominent biomarkers. The Sperm Associated antigen 5 …

Cell cycle and apoptosis regulator 2 (CCAR2), also known as deleted in breast cancer 1
(DBC1), has been recently identified as a master regulator of transcriptional processes and …

Mitochondria, traditionally known as cellular powerhouses, now emerge as critical signaling
centers influencing cancer progression and drug resistance. The review highlights the role …

Dear Editor, Prostate cancer (PCa) is traditionally considered an immunologically cold
tumour characterized by an immunosuppressive tumour microenvironment (TME) and a …

Currently, eight million people in the United States suffer from cancer and it is a major global
health concern. Early detection and interventions are urgently needed for all cancers …