Redox imbalance stress in diabetes mellitus: Role of the polyol pathway
L Yan - Animal models and experimental medicine, 2018 - Wiley Online Library
In diabetes mellitus, the polyol pathway is highly active and consumes approximately 30%
glucose in the body. This pathway contains 2 reactions catalyzed by aldose reductase (AR) …
glucose in the body. This pathway contains 2 reactions catalyzed by aldose reductase (AR) …
Functionalized quinoxalinones as privileged structures with broad-ranging pharmacological activities
X Jiang, K Wu, R Bai, P Zhang, Y Zhang - European Journal of Medicinal …, 2022 - Elsevier
Quinoxalinones are a class of heterocyclic compounds which attract extensive attention
owing to their potential in the field of organic synthesis and medicinal chemistry. During the …
owing to their potential in the field of organic synthesis and medicinal chemistry. During the …
Diarylmethanon, bromophenol and diarylmethane compounds: Discovery of potent aldose reductase, α-amylase and α-glycosidase inhibitors as new therapeutic …
Diabetes mellitus (DM) is a chronic metabolic disease in which there are high blood sugar
levels over a prolonged period. Aldose reductase (AR) belongs to aldo-keto reductase …
levels over a prolonged period. Aldose reductase (AR) belongs to aldo-keto reductase …
Antidiabetic properties of dietary phenolic compounds: Inhibition effects on α‐amylase, aldose reductase, and α‐glycosidase
Abstract Aldose reductase (AR), α‐amylase, and α‐glycosidase are vital enzymes to prevent
diabetic complications. Here, AR was purified from sheep kidney using elementary methods …
diabetic complications. Here, AR was purified from sheep kidney using elementary methods …
Antidiabetic potential: In vitro inhibition effects of bromophenol and diarylmethanones derivatives on metabolic enzymes
Aldose reductase converts glucose to sorbitol in the polyol pathway. It is an important
enzyme to prevent diabetic complications. In this study, we studied the inhibitory effects of …
enzyme to prevent diabetic complications. In this study, we studied the inhibitory effects of …
Anti-diabetic properties of calcium channel blockers: inhibition effects on aldose reductase enzyme activity
Aldose reductase (AR) belongs to NADPH-dependent oxidoreductases and converts
glucose to sorbitol in the polyol pathway. AR inhibition is essential to prevent diabetic …
glucose to sorbitol in the polyol pathway. AR inhibition is essential to prevent diabetic …
Aldose reductase and protein tyrosine phosphatase 1B inhibitors as a promising therapeutic approach for diabetes mellitus
A Kousaxidis, A Petrou, V Lavrentaki… - European Journal of …, 2020 - Elsevier
Diabetes mellitus is a metabolic disease characterized by high blood glucose levels and
usually associated with several chronic pathologies. Aldose reductase and protein tyrosine …
usually associated with several chronic pathologies. Aldose reductase and protein tyrosine …
Inhibition effects of quinones on aldose reductase: antidiabetic properties
Diabetes mellitus is a chronic metabolic disease characterized by abnormal glucose
metabolism. Aldose reductase (AR) is the first enzyme in the polyol pathway and converts …
metabolism. Aldose reductase (AR) is the first enzyme in the polyol pathway and converts …
Phenolic compounds inhibit the aldose reductase enzyme from the sheep kidney
Aldose reductase (AR) is the key enzyme for the polyol pathway and responsible for sorbitol
accumulation during the hyperglycemia. The present article focuses on the role of phenol …
accumulation during the hyperglycemia. The present article focuses on the role of phenol …
Pd (TFA) 2-catalyzed direct arylation of quinoxalinones with arenes
H DattaáKhanal, C DharáClinton… - Organic Chemistry …, 2019 - pubs.rsc.org
The direct C-3 arylation of quinoxalin-2-ones with arenes is achieved by a Pd (TFA) 2-
catalyzed cross-dehydrogenative coupling (CDC) reaction. A wide array of functionalities …
catalyzed cross-dehydrogenative coupling (CDC) reaction. A wide array of functionalities …