Background The omicron variant (B. 1.1. 529) of SARS-CoV-2 has demonstrated partial
vaccine escape and high transmissibility, with early studies indicating lower severity of …

The COVID-19 pandemic led to 231,841 deaths and 940,243 hospitalisations in England, by
the end of March 2023. This paper calculates the real-time infection hospitalisation risk (IHR) …

The Omicron variant of SARS-CoV-2 became the globally dominant variant in early 2022. A
sub-lineage of the Omicron variant (BA. 2) was identified in England in January 2022. Here …

Objectives To determine how the intrinsic severity of successively dominant SARS-CoV-2
variants changed over the course of the pandemic. Methods A retrospective cohort analysis …

Objectives To estimate the risk of hospitalization among reported cases of the Delta variant
of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) compared with the Alpha …

Widespread vaccination campaigns have changed the landscape for COVID-19, vastly
altering symptoms and reducing morbidity and mortality. We estimate trends in mortality by …

New SARS-CoV-2 variants causing COVID-19 are a major risk to public health worldwide
due to the potential for phenotypic change and increases in pathogenicity, transmissibility …

Several SARS-CoV-2 variants that evolved during the COVID-19 pandemic have appeared
to differ in severity, based on analyses of single-country datasets. With decreased testing …

To investigate if the AY. 4.2 sublineage of the SARS-CoV-2 delta variant is associated with
hospitalization and mortality risks that differ from non-AY. 4.2 delta risks, we performed a …

Objective To determine how the severity of successively dominant SARS-CoV-2 variants has
changed over the course of the COVID-19 pandemic. Design Prospective cohort analysis …