Microglia, the resident immune cells of the central nervous system (CNS), are crucial for
normal brain development and function. They become reactive in response to brain injury …

Peripheral immune cells play an important role in the pathology of Alzheimer's disease (AD),
impacting processes such as amyloid and tau protein aggregation, glial activation, neuronal …

Neurodegenerative and neuropsychiatric diseases impose a significant societal and public
health burden. However, our understanding of the molecular mechanisms underlying these …

Pathophysiological evolutions in early-stage Alzheimer's disease (AD) are not well
understood. We used data of 2923 Olink plasma proteins from 51,296 non-demented middle …

Alzheimer's disease (AD) is a complex neurodegenerative disorder that currently lacks
effective treatment options. This study aimed to identify potential therapeutic targets for the …

Cellular senescence is a cell state triggered by programmed physiological processes or
cellular stress responses. Stress-induced senescent cells often acquire pathogenic traits …

Circulating immune cells contribute to the pathogenesis of Alzheimer's disease (AD), but
their role is poorly understood. Rosenzweig et al. recently identified a subset of interleukin …

A recent study published in Nature Medicine uncovers a novel sexdependent mechanism
involving the apolipoprotein E ε4 (APOE4) and in particular neutrophils and their signaling to …

Midlife cardiovascular risk factors such as Type 2 Diabetes (T2DM) and obesity are
associated with the later development of cognitive impairment and dementia. Systemic …