Cell death pathways have evolved to maintain tissue homoeostasis and eliminate potentially
harmful cells from within an organism, such as cells with damaged DNA that could lead to …

Cancer is one of the most common causes of death. So, its lethal effect increases with time.
Near about hundreds of cancers are known in humans. Cancer treatment is done to cure or …

Forty years ago, ubiquitin was first discovered as a posttranslational modification earmarking
proteins for degradation [1]. This seminal, biochemical work laid the foundation for countless …

Hepatocellular carcinoma (HCC) is a lethal and aggressive human malignancy. The present
study examins the anti‐tumor effects of deubiquitylating enzymes (DUB) inhibitors in HCC. It …

Objective Glioblastoma is one of the most common intracranial malignant tumors with an
unfavorable prognosis, and iron metabolism as well as ferroptosis are implicated in the …

Targeted protein degradation (TPD) is an emerging therapeutic strategy that would benefit
from new chemical entities with which to recruit a wider variety of ubiquitin E3 ligases to …

Tripartite motif-containing protein 7 (TRIM7), as an E3 ligase, plays an important regulatory
role in various physiological and pathological processes. However, the role of TRIM7 in …

Background Resistance to temozolomide (TMZ) is a major obstacle to preventing
glioblastoma (GBM) recurrence after surgery. Although long noncoding RNAs (lncRNAs) …

Abstract Caspase-8, a renowned cysteine-aspartic protease within its enzyme family, initially
garnered attention for its regulatory role in extrinsic apoptosis. With advancing research, a …

PROteolysis TArgeting Chimera (PROTAC) is an emerging technology in chemical biology
and drug discovery. This technique facilitates the complete removal of the target proteins …