Targeting mitophagy in neurodegenerative diseases
O Antico, PW Thompson, NT Hertz… - Nature Reviews Drug …, 2025 - nature.com
Mitochondrial dysfunction is a hallmark of idiopathic neurodegenerative diseases, including
Parkinson disease, amyotrophic lateral sclerosis, Alzheimer disease and Huntington …
Parkinson disease, amyotrophic lateral sclerosis, Alzheimer disease and Huntington …
Integrative approach of omics and imaging data to discover new insights for understanding brain diseases
Treatments that can completely resolve brain diseases have yet to be discovered. Omics is a
novel technology that allows researchers to understand the molecular pathways underlying …
novel technology that allows researchers to understand the molecular pathways underlying …
Acetyl-DL-leucine in two individuals with REM sleep behavior disorder improves symptoms, reverses loss of striatal dopamine-transporter binding and stabilizes …
Abstract Isolated REM Sleep Behavior Disorder (iRBD) is considered a prodrome of
Parkinson's disease (PD). We investigate whether the potentially disease-modifying …
Parkinson's disease (PD). We investigate whether the potentially disease-modifying …
Functional connectome through the human life span
The lifespan growth of the functional connectome remains unknown. Here, we assemble
task-free functional and structural magnetic resonance imaging data from 33,250 individuals …
task-free functional and structural magnetic resonance imaging data from 33,250 individuals …
Disruptions in segregation mechanisms in fmri-based brain functional network predict the major depressive disorder condition
This study investigates the functional brain network in major depressive disorder using
network theory and a consensus network approach. At the macroscopic level, we found …
network theory and a consensus network approach. At the macroscopic level, we found …
A network imaging biomarker of X‐linked dystonia‐parkinsonism
M Niethammer, CC Tang, RDG Jamora… - Annals of …, 2023 - Wiley Online Library
Objective The purpose of this study was to characterize a metabolic brain network
associated with X‐linked dystonia‐parkinsonism (XDP). Methods Thirty right‐handed …
associated with X‐linked dystonia‐parkinsonism (XDP). Methods Thirty right‐handed …
Toward interpretability of machine learning methods for the classification of patients with major depressive disorder based on functional network measures
We address the interpretability of the machine learning algorithm in the context of the
relevant problem of discriminating between patients with major depressive disorder (MDD) …
relevant problem of discriminating between patients with major depressive disorder (MDD) …
A candidate loss-of-function variant in SGIP1 causes synaptic dysfunction and recessive parkinsonism
M Decet, P Scott, S Kuenen, D Meftah, J Swerts… - Cell Reports …, 2024 - cell.com
Synaptic dysfunction is recognized as an early step in the pathophysiology of parkinsonism.
Several genetic mutations affecting the integrity of synaptic proteins cause or increase the …
Several genetic mutations affecting the integrity of synaptic proteins cause or increase the …
[HTML][HTML] Functional Brain Networks to Evaluate Treatment Responses in Parkinson's Disease
Network analysis of functional brain scans acquired with [18 F]-fluorodeoxyglucose positron
emission tomography (FDG PET, to map cerebral glucose metabolism), or resting-state …
emission tomography (FDG PET, to map cerebral glucose metabolism), or resting-state …
Systematic evaluation of fMRI data-processing pipelines for consistent functional connectomics
Functional interactions between brain regions can be viewed as a network, enabling
neuroscientists to investigate brain function through network science. Here, we …
neuroscientists to investigate brain function through network science. Here, we …