The genetically encoded fluorescent sensors convert chemical and physical signals into
light. They are powerful tools for the visualisation of physiological processes in living cells …

Zinc fingers (ZFs) are among the most structurally diverse protein domains. They interact
with nucleic acids, other proteins and lipids to facilitate a multitude of biological processes …

Mammalian cell nuclei contain copper, and cancer cells are known to accumulate aberrantly
high copper levels, yet the mechanisms underlying nuclear accumulation and copper's …

Metal ions are commonly found as protein co-factors in biology, and it is estimated that over
a quarter of all proteins require a metal cofactor. The distribution and utilization of metals in …

Liquid-liquid phase separation (LLPS) is a rapidly growing research focus due to numerous
demonstrations that many cellular proteins phase-separate to form biomolecular …

The host limits Mycobacterium tuberculosis (Mtb) by enriching copper in high
concentrations. This research investigates how Mtb escapes copper stress. The membrane …

Tristetraprolin (TTP) is a nonclassical zinc finger (ZF) protein that plays a key role in
regulating inflammatory response. TTP regulates cytokines at the mRNA level by binding to …

Molecular dynamics (MD) simulations are a powerful approach to studying the structure and
dynamics of proteins related to health and disease. Advances in the MD field allow modeling …

ZF proteins are ubiquitous eukaryotic proteins that play important roles in gene regulation.
ZFs contain small domains made up of a combination of four cysteine and histidine residues …

Tristetraprolin (TTP) is a nonclassical CCCH zinc finger protein that regulates inflammation.
TTP targets AU-rich RNA sequences of cytokine mRNAs forming a TTP/mRNA complex. This …