Autophagy is an essential cellular process affecting virus infections and other diseases and
Beclin1 (BECN1) is one of its key regulators. Here, we identified S-phase kinase-associated …

Coronaviruses (CoVs) stand out for their large RNA genome and complex RNA-synthesizing
machinery comprising 16 nonstructural proteins (nsps). The bifunctional nsp14 contains 3 …

Natural killer (NK) cells are innate lymphocytes that lack antigen-specific rearranged
receptors, a hallmark of adaptive lymphocytes. In some people infected with human …

Background Trimethylamine (TMA), produced by the gut microbiota from dietary quaternary
amines (mainly choline and carnitine), is associated with atherosclerosis and severe …

In addition to members causing milder human infections, the Coronaviridae family includes
potentially lethal zoonotic agents causing severe acute respiratory syndrome (SARS) and …

Herpesviruses assemble large enveloped particles that are difficult to characterize
structurally due to their size, fragility and complex multilayered proteome with partially …

The sensor RIG-I detects double-stranded RNA derived from RNA viruses. Although RIG-I is
also known to have a role in the antiviral response to DNA viruses, physiological RNA …

The current dogma of RNA-mediated innate immunity is that sensing of immunostimulatory
RNA ligands is sufficient for the activation of intracellular sensors and induction of interferon …

Summary The SARS-CoV-2 virus, the causative agent of COVID-19, is undergoing constant
mutation. Here, we utilized an integrative approach combining epidemiology, virus genome …

Maintenance and manipulation of large DNA and RNA virus genomes had presented an
obstacle for virological research. BAC vectors provided a solution to both problems as they …