The gut microbiome as a modulator of healthy ageing
The gut microbiome is a contributory factor in ageing-related health loss and in several non-
communicable diseases in all age groups. Some age-linked and disease-linked …
communicable diseases in all age groups. Some age-linked and disease-linked …
Short chain fatty acids: microbial metabolites for gut-brain axis signalling
KJ O'Riordan, MK Collins, GM Moloney… - Molecular and Cellular …, 2022 - Elsevier
The role of the intestinal microbiota as a regulator of gut-brain axis signalling has risen to
prominence in recent years. Understanding the relationship between the gut microbiota, the …
prominence in recent years. Understanding the relationship between the gut microbiota, the …
Gut microbiome composition may be an indicator of preclinical Alzheimer's disease
Alzheimer's disease (AD) pathology is thought to progress from normal cognition through
preclinical disease and ultimately to symptomatic AD with cognitive impairment. Recent work …
preclinical disease and ultimately to symptomatic AD with cognitive impairment. Recent work …
Challenges and hopes for Alzheimer's disease
SA Tatulian - Drug discovery today, 2022 - Elsevier
Recent drug development efforts targeting Alzheimer's disease (AD) have failed to produce
effective disease-modifying agents for many reasons, including the substantial …
effective disease-modifying agents for many reasons, including the substantial …
Microbiota in neuroinflammation and synaptic dysfunction: a focus on Alzheimer's disease
D Bairamian, S Sha, N Rolhion, H Sokol… - Molecular …, 2022 - Springer
Background The implication of gut microbiota in the control of brain functions in health and
disease is a novel, currently emerging concept. Accumulating data suggest that the gut …
disease is a novel, currently emerging concept. Accumulating data suggest that the gut …
Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia
E Connell, G Le Gall, MG Pontifex, S Sami… - Molecular …, 2022 - Springer
A consequence of our progressively ageing global population is the increasing prevalence
of worldwide age-related cognitive decline and dementia. In the absence of effective …
of worldwide age-related cognitive decline and dementia. In the absence of effective …
Microbiota-derived metabolites as drivers of gut–brain communication
Alterations in the gut microbiota composition have been associated with a range of
neurodevelopmental, neurodegenerative, and neuropsychiatric disorders. The gut microbes …
neurodevelopmental, neurodegenerative, and neuropsychiatric disorders. The gut microbes …
Microbiota from Alzheimer's patients induce deficits in cognition and hippocampal neurogenesis
S Grabrucker, M Marizzoni, E Silajdžić, N Lopizzo… - Brain, 2023 - academic.oup.com
Alzheimer's disease is a complex neurodegenerative disorder leading to a decline in
cognitive function and mental health. Recent research has positioned the gut microbiota as …
cognitive function and mental health. Recent research has positioned the gut microbiota as …
Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition
Previous studies have identified a crucial role of the gut microbiome in modifying
Alzheimer's disease (AD) progression. However, the mechanisms of microbiome–brain …
Alzheimer's disease (AD) progression. However, the mechanisms of microbiome–brain …
[HTML][HTML] Interplay of gut microbiota and oxidative stress: Perspective on neurodegeneration and neuroprotection
S Shandilya, S Kumar, NK Jha, KK Kesari… - Journal of Advanced …, 2022 - Elsevier
Background Recent research on the implications of gut microbiota on brain functions has
helped to gather important information on the relationship between them. Pathogenesis of …
helped to gather important information on the relationship between them. Pathogenesis of …