Dual variable domain immunoglobin and uses thereof
C Wu, T Ghayur, RW Dixon, JG Salfeld - 2007 - Google Patents
NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O= C ([C@ H](CO) NC
(= O)[C@ H](CC (C) C) NC (= O)[C@ H](CC (O)= O) NC (= O)[C@ H](CC (C) C) NC …
(= O)[C@ H](CC (C) C) NC (= O)[C@ H](CC (O)= O) NC (= O)[C@ H](CC (C) C) NC …
Antibody composition-containing medicament
R Niwa, K Shitara - US Patent 7,691,568, 2010 - Google Patents
(57) ABSTRACT A medicament for treating a patient Who cannot be cured With a
medicament comprising as an active ingredient an antibody composition produced by a cell …
medicament comprising as an active ingredient an antibody composition produced by a cell …
Fc variants with altered binding to FcRn
AK Chamberlain, BI Dahiyat, JR Desjarlais… - US Patent …, 2013 - Google Patents
The present application relates to a variant Fc region com prising at least one modification
relative to a wild-type human Fc region, where the modification selected from the group …
relative to a wild-type human Fc region, where the modification selected from the group …
Dual variable domain immunoglobulins and uses thereof
T Ghayur, PC Isakson, LM Olson, C Wu… - US Patent …, 2015 - Google Patents
US9035027B2 - Dual variable domain immunoglobulins and uses thereof - Google Patents
US9035027B2 - Dual variable domain immunoglobulins and uses thereof - Google Patents …
US9035027B2 - Dual variable domain immunoglobulins and uses thereof - Google Patents …
Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
GA Lazar, GL Moore - US Patent 9,493,578, 2016 - Google Patents
YSFTYXKQUONNFY-NQXPEFQPSA-N FGF2 Chemical compound C ([C@@ H](C (= O) N
[C@@ H](CCCCN) C (= O) N [C@@ H](CC (O)= O) C (= O) N1CCC [C@ H] 1C (= O) N …
[C@@ H](CCCCN) C (= O) N [C@@ H](CC (O)= O) C (= O) N1CCC [C@ H] 1C (= O) N …
Heterodimeric proteins
G Moore, M Bernett, R Rashid, J Desjarlais - US Patent 10,858,417, 2020 - Google Patents
In one aspect, the present invention provides heterodimeric antibodies comprising a first
monomer comprising a first heavy chain constant domain comprising a first variant Fc …
monomer comprising a first heavy chain constant domain comprising a first variant Fc …
Dual variable domain immunoglobulin and uses thereof
C Wu, T Ghayur, RW Dixon, JG Salfeld - US Patent 8,258,268, 2012 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
39107276&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
39107276&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
Heterodimeric proteins
G Moore, M Bernett, R Rashid, J Desjarlais - US Patent 9,650,446, 2017 - Google Patents
C07K16/2809—Immunoglobulins [IGs], eg monoclonal or polyclonal antibodies against
material from animals or humans against receptors, cell surface antigens or cell surface …
material from animals or humans against receptors, cell surface antigens or cell surface …
Optimized antibody variable regions
G Moore, M Bernett, R Rashid, J Desjarlais - US Patent 10,131,710, 2018 - Google Patents
The present invention is directed to optimized anti-CD3 variable sequences for use in a
variety of bispecific formats, including those that utilize scFv components. The invention …
variety of bispecific formats, including those that utilize scFv components. The invention …
Heterodimeric proteins
JR Desjarlais, GL Moore, R Rashid… - US Patent …, 2017 - Google Patents
C07K16/2809—Immunoglobulins [IGs], eg monoclonal or polyclonal antibodies against
material from animals or humans against receptors, cell surface antigens or cell surface …
material from animals or humans against receptors, cell surface antigens or cell surface …