Lipid rafts: controversies resolved, mysteries remain
The lipid raft hypothesis postulates that lipid–lipid interactions can laterally organize
biological membranes into domains of distinct structures, compositions, and functions. This …
biological membranes into domains of distinct structures, compositions, and functions. This …
The mystery of membrane organization: composition, regulation and roles of lipid rafts
Cellular plasma membranes are laterally heterogeneous, featuring a variety of distinct
subcompartments that differ in their biophysical properties and composition. A large number …
subcompartments that differ in their biophysical properties and composition. A large number …
Structural determinants and functional consequences of protein affinity for membrane rafts
Eukaryotic plasma membranes are compartmentalized into functional lateral domains,
including lipid-driven membrane rafts. Rafts are involved in most plasma membrane …
including lipid-driven membrane rafts. Rafts are involved in most plasma membrane …
The continuing mystery of lipid rafts
Since its initial formalization nearly 20 years ago, the concept of lipid rafts has generated a
tremendous amount of attention and interest and nearly as much controversy. The …
tremendous amount of attention and interest and nearly as much controversy. The …
Protein sorting by lipid phase-like domains supports emergent signaling function in B lymphocyte plasma membranes
Diverse cellular signaling events, including B cell receptor (BCR) activation, are
hypothesized to be facilitated by domains enriched in specific plasma membrane lipids and …
hypothesized to be facilitated by domains enriched in specific plasma membrane lipids and …
There is no simple model of the plasma membrane organization
Ever since technologies enabled the characterization of eukaryotic plasma membranes,
heterogeneities in the distributions of its constituents were observed. Over the years this led …
heterogeneities in the distributions of its constituents were observed. Over the years this led …
The actin homologue MreB organizes the bacterial cell membrane
The eukaryotic cortical actin cytoskeleton creates specific lipid domains, including lipid rafts,
which determine the distribution of many membrane proteins. Here we show that the …
which determine the distribution of many membrane proteins. Here we show that the …
Correlation functions quantify super-resolution images and estimate apparent clustering due to over-counting
We present an analytical method using correlation functions to quantify clustering in super-
resolution fluorescence localization images and electron microscopy images of static …
resolution fluorescence localization images and electron microscopy images of static …
A survey of models of cell membranes: toward a new understanding of membrane organization
The cell membrane, the boundary that separates living cells from their environment, has
been the subject of study for over a century. The fluid-mosaic model of Singer and Nicolson …
been the subject of study for over a century. The fluid-mosaic model of Singer and Nicolson …
EGFR oligomerization organizes kinase-active dimers into competent signalling platforms
SR Needham, SK Roberts, A Arkhipov… - Nature …, 2016 - nature.com
Epidermal growth factor receptor (EGFR) signalling is activated by ligand-induced receptor
dimerization. Notably, ligand binding also induces EGFR oligomerization, but the structures …
dimerization. Notably, ligand binding also induces EGFR oligomerization, but the structures …