The mammalian heart is responsible for not only pum** blood throughout the body but
also adjusting this pum** activity quickly depending upon sudden changes in the …

The giant sarcomere protein titin is a major determinant of cardiomyocyte stiffness and
contributor to cardiac strain sensing. Titin-based forces are highly regulated in health and …

Background—The purpose of this study was to determine whether patients with heart failure
and a preserved ejection fraction (HFpEF) have an increase in passive myocardial stiffness …

Background Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-
CMs) have great potential as a cell source for therapeutic applications such as regenerative …

Half of patients with heart failure (HF) have a preserved left ventricular ejection fraction
(HFpEF). Morbidity and mortality in HFpEF are similar to values observed in patients with HF …

Diastolic heart failure (DHF) currently accounts for more than 50% of all heart failure
patients. DHF is also referred to as heart failure with normal left ventricular (LV) ejection …

The giant protein titin forms a unique filament network in cardiomyocytes, which engages in
both mechanical and signaling functions of the heart. TTN, which encodes titin, is also a …

The thin and thick filaments of muscle sarcomeres are interconnected by the giant protein
titin, which is a scaffolding filament, signaling platform, and provider of passive tension and …

Heart failure (HF) is a complex syndrome that affects approximately 6.5 million adults in the
United States. About half of the 6.5 million adults with HF are estimated to be individuals with …

Alternative splicing has a major role in cardiac adaptive responses, as exemplified by the
isoform switch of the sarcomeric protein titin, which adjusts ventricular filling. By positional …