Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …

Atherosclerosis is a chronic inflammatory disease; unstable atherosclerotic plaque rupture,
vascular stenosis, or occlusion caused by platelet aggregation and thrombosis lead to acute …

Cells of the vascular wall are exquisitely sensitive to changes in their mechanical
environment. In healthy vessels, mechanical forces regulate signaling and gene expression …

Current knowledge suggests that intimal smooth muscle cells (SMCs) in native
atherosclerotic plaque derive mainly from the medial arterial layer. During this process …

Vascular smooth muscle cells (VSMCs) are the major cell type in blood vessels. Unlike
many other mature cell types in the adult body, VSMC do not terminally differentiate but …

The vascular endothelium is constantly exposed to mechanical forces, including fluid shear
stress exerted by the flowing blood. Endothelial cells can sense different flow patterns and …

Arterial remodeling refers to the structural and functional changes of the vessel wall that
occur in response to disease, injury, or aging. Vascular smooth muscle cells (VSMC) play a …

Integrins are heterodimeric glycoproteins crucial to the physiology and pathology of many
biological functions. As adhesion molecules, they mediate immune cell trafficking, migration …

Lipoprotein (a)[Lp (a)], aka “Lp little a”, was discovered in the 1960s in the lab of the
Norwegian physician Kåre Berg. Since then, we have greatly improved our knowledge of …

Normally, smooth muscle cells (SMCs) are localized in the tunica media of the vasculature,
where they take responsibility for vascular contraction and extracellular matrix (ECM) …