Diabetes, a complex multisystem metabolic disorder characterized by hyperglycemia, leads
to complications that reduce quality of life and increase mortality. Diabetes pathophysiology …

Nearly every mammalian cell division is accompanied by a mutational event that becomes
fixed in a daughter cell. When carried forward to additional cell progeny, a clone of variant …

Mitochondria are critical for proper organ function and mechanisms to promote
mitochondrial health during regeneration would benefit tissue homeostasis. We report that …

Loss of stem cell regenerative potential underlies aging of all tissues. Somatic mosaicism,
the emergence of cellular patchworks within tissues, increases with age and has been …

Liver diseases have consistently posed substantial challenges to global health. It is crucial
to find innovative methods to effectively prevent and treat these diseases. In recent times …

Hepatocellular carcinoma is one of the deadliest and fastest‐growing cancers. Among HCC
etiologies, metabolic dysfunction‐associated fatty liver disease (MAFLD) has served as a …

Liver-tissue engineering has proven valuable in treating liver diseases, but the construction
of liver tissues with high fidelity remains challenging. Here, we present a novel three …

Non-alcoholic fatty liver disease (NAFLD) is a multifactorial condition with a complex
etiology. Its incidence is increasing globally in parallel with the obesity epidemic, and it is …

Chronic liver disease stands as a significant global health problem with an estimated 2
million annual deaths across the globe. Combining the use of next-generation sequencing …

Cellular plasticity in adult multicellular organisms is a protective mechanism that allows
certain tissues to regenerate in response to injury. Considering that aging involves exposure …