This review is focused on the structural and physicochemical aspects of metal cation
coordination to G-Quadruplexes (GQ) and their effects on GQ stability and conformation. G …

Quadruplex-forming sequences are widely prevalent in human and other genomes,
including bacterial ones. These sequences are over-represented in eukaryotic telomeres …

In addition to the canonical double helix, DNA can fold into various other inter-and
intramolecular secondary structures. Although many such structures were long thought to be …

A G-quadruplex (G4) is a well-known nucleic acid secondary structure comprising guanine-
rich sequences, and has profound implications for various pharmacological and biological …

Guanine-rich nucleic acids can fold into the non-B DNA or RNA structures called G-
quadruplexes (G4). Recent methodological developments have allowed the characterization …

G-quadruplexes are four-stranded DNA structures that are over-represented in gene
promoter regions and are viewed as emerging therapeutic targets in oncology, as …

A Hybrid drug which comprises the incorporation of two drug pharmacophores in one single
molecule are basically designed to interact with multiple targets or to amplify its effect …

Guanine-rich RNA sequences can fold into four-stranded structures, termed G-quadruplexes
(G4-RNAs), whose biological roles are poorly understood, and in vivo existence is debated …

A complete understanding of DNA double-helical structure discovered by James Watson
and Francis Crick in 1953, unveil the importance and significance of DNA. For the last seven …

The presence and biological importance of DNA secondary structures in eukaryotic
promoters are becoming increasingly recognized among chemists and biologists as …