Paraspeckles: where long noncoding RNA meets phase separation
Long noncoding RNA (lncRNA) molecules are some of the newest and least understood
players in gene regulation. Hence, we need good model systems with well-defined RNA and …
players in gene regulation. Hence, we need good model systems with well-defined RNA and …
Biogenesis and function of nuclear bodies
YS Mao, B Zhang, DL Spector - Trends in Genetics, 2011 - cell.com
Nuclear bodies including nucleoli, Cajal bodies, nuclear speckles, Polycomb bodies, and
paraspeckles are membraneless subnuclear organelles. They are present at steady-state …
paraspeckles are membraneless subnuclear organelles. They are present at steady-state …
Fundamental properties of the mammalian innate immune system revealed by multispecies comparison of type I interferon responses
The host innate immune response mediated by type I interferon (IFN) and the resulting up-
regulation of hundreds of interferon-stimulated genes (ISGs) provide an immediate barrier to …
regulation of hundreds of interferon-stimulated genes (ISGs) provide an immediate barrier to …
Long noncoding RNA NEAT1-dependent SFPQ relocation from promoter region to paraspeckle mediates IL8 expression upon immune stimuli
K Imamura, N Imamachi, G Akizuki, M Kumakura… - Molecular cell, 2014 - cell.com
Although thousands of long noncoding RNAs (lncRNAs) are localized in the nucleus, only a
few dozen have been functionally characterized. Here we show that nuclear enriched …
few dozen have been functionally characterized. Here we show that nuclear enriched …
NEAT1 long noncoding RNA regulates transcription via protein sequestration within subnuclear bodies
T Hirose, G Virnicchi, A Tanigawa… - Molecular biology of …, 2014 - molbiolcell.org
Paraspeckles are subnuclear structures formed around nuclear paraspeckle assembly
transcript 1 (NEAT1)/MENε/β long noncoding RNA (lncRNA). Here we show that …
transcript 1 (NEAT1)/MENε/β long noncoding RNA (lncRNA). Here we show that …
Long non-coding RNAs in the regulation of the immune response
JA Heward, MA Lindsay - Trends in immunology, 2014 - cell.com
It is increasingly clear that long non-coding RNAs (lncRNAs) regulate a variety biological
responses, and that they do so by a diverse range of mechanisms. In the field of …
responses, and that they do so by a diverse range of mechanisms. In the field of …
Identification of the long noncoding RNA NEAT1 as a novel inflammatory regulator acting through MAPK pathway in human lupus
Long noncoding RNAs (lncRNAs) have recently been identified to be tightly linked to diverse
human diseases. However, our knowledge of Systemic Lupus Erythematosus (SLE)-related …
human diseases. However, our knowledge of Systemic Lupus Erythematosus (SLE)-related …
A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains
JN Hutchinson, AW Ensminger, CM Clemson… - BMC genomics, 2007 - Springer
Background Noncoding RNA species play a diverse set of roles in the eukaryotic cell. While
much recent attention has focused on smaller RNA species, larger noncoding transcripts are …
much recent attention has focused on smaller RNA species, larger noncoding transcripts are …
lncRNAdb: a reference database for long noncoding RNAs
Large numbers of long RNAs with little or no protein-coding potential [long noncoding RNAs
(lncRNAs)] are being identified in eukaryotes. In parallel, increasing data describing the …
(lncRNAs)] are being identified in eukaryotes. In parallel, increasing data describing the …
MEN ε/β nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles
Studies of the transcriptional output of the human and mouse genomes have revealed that
there are many more transcripts produced than can be accounted for by predicted protein …
there are many more transcripts produced than can be accounted for by predicted protein …