Messenger RNA (mRNA) therapeutics have been widely employed as strategies for the
treatment and prevention of diseases. Amid the global outbreak of COVID-19, mRNA …

During their synthesis in the cell nucleus, most eukaryotic mRNAs undergo a two‐step 3′‐
end processing reaction in which the pre‐mRNA is cleaved and released from the …

The transcriptional induction of interferon (IFN) genes is a key feature of the mammalian
antiviral response that limits viral replication and dissemination. A hallmark of severe COVID …

RNA concentration homeostasis involves coordinating RNA abundance and synthesis rates
with cell size. Here, we study this in human cells by combining genome-wide perturbations …

In response to foreign and endogenous double-stranded RNA (dsRNA), protein kinase R
(PKR) and ribonuclease L (RNase L) reprogram translation in mammalian cells. PKR …

Nuclear clearance of the RNA-binding protein TDP-43 is a hallmark of neurodegeneration
and an important therapeutic target. Our current understanding of TDP-43 …

RNA is a central molecule for viruses; however, the interactions that viral RNA (vRNA)
establishes with the host cell is only starting to be elucidated. Here, we determine the …

Many viruses induce shutoff of host gene expression (host shutoff) as a strategy to take over
cellular machinery and evade host immunity. Without host shutoff activity, these viruses …

The antiviral endoribonuclease, RNase L, is activated by the mammalian innate immune
response to destroy host and viral RNA to ultimately reduce viral gene expression. Herein …

Differential expression analysis of RNA sequencing (RNA-seq) data can identify changes in
cellular RNA levels, but provides limited information about the kinetic mechanisms …