The gut microbiome: Relationships with disease and opportunities for therapy

J Durack, SV Lynch - Journal of experimental medicine, 2019 - rupress.org
Introduction to the field of microbiome research Over evolutionary time, humans have
developed symbiotically with a diversity of environmental microbial species (Sender et al …

Gamma-aminobutyric acid signaling in damage response, metabolism, and disease

K Kim, H Yoon - International Journal of Molecular Sciences, 2023 - mdpi.com
Gamma-aminobutyric acid (GABA) plays a crucial role in signal transduction and can
function as a neurotransmitter. Although many studies have been conducted on GABA in …

Dietary fiber modulates the release of gut bacterial products preventing cognitive decline in an Alzheimer's mouse model

D Cuervo-Zanatta, T Syeda, V Sánchez-Valle… - Cellular and Molecular …, 2023 - Springer
Fiber intake is associated with a lower risk for Alzheimer´ s disease (AD) in older adults.
Intake of plant-based diets rich in soluble fiber promotes the production of short-chain fatty …

Imaging brain glucose metabolism in vivo reveals propionate as a major anaplerotic substrate in pyruvate dehydrogenase deficiency

I Marin-Valencia, A Kocabas, C Rodriguez-Navas… - Cell metabolism, 2024 - cell.com
A vexing problem in mitochondrial medicine is our limited capacity to evaluate the extent of
brain disease in vivo. This limitation has hindered our understanding of the mechanisms that …

Propionate and Alzheimer's disease

J Killingsworth, D Sawmiller, RD Shytle - Frontiers in aging …, 2021 - frontiersin.org
Propionate, a short-chain fatty acid, serves important roles in the human body. However, our
review of the current literature suggests that under certain conditions, excess levels of …

Human forebrain organoid-based multi-omics analyses of PCCB as a schizophrenia associated gene linked to GABAergic pathways

W Zhang, M Zhang, Z Xu, H Yan, H Wang… - Nature …, 2023 - nature.com
Identifying genes whose expression is associated with schizophrenia (SCZ) risk by
transcriptome-wide association studies (TWAS) facilitates downstream experimental studies …

Central and peripheral regulations mediated by short-chain fatty acids on energy homeostasis

P Luo, K Lednovich, K Xu, C Nnyamah, BT Layden… - Translational …, 2022 - Elsevier
The human gut microbiota influences obesity, insulin resistance, and the subsequent
development of type 2 diabetes (T2D). The gut microbiota digests and ferments nutrients …

Ifosfamide-History, efficacy, toxicity and encephalopathy

JR Idle, D Beyoğlu - Pharmacology & Therapeutics, 2023 - Elsevier
In this review we trace the passage of fundamental ideas through 20 th century cancer
research that began with observations on mustard gas toxicity in World War I. The …

Antibiotics and the develo** intestinal microbiome, metabolome and inflammatory environment in a randomized trial of preterm infants

JT Russell, J Lauren Ruoss, D de la Cruz, N Li… - Scientific Reports, 2021 - nature.com
Antibiotic use in neonates can have detrimental effects on the develo** gut microbiome,
increasing the risk of morbidity. A majority of preterm neonates receive antibiotics after birth …

Pathophysiological mechanisms of complications associated with propionic acidemia

H Marchuk, Y Wang, ZA Ladd, X Chen… - Pharmacology & …, 2023 - Elsevier
Propionic acidemia (PA) is a genetic metabolic disorder caused by mutations in the
mitochondrial enzyme, propionyl-CoA carboxylase (PCC), which is responsible for …