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The gut microbiome: Relationships with disease and opportunities for therapy
Introduction to the field of microbiome research Over evolutionary time, humans have
developed symbiotically with a diversity of environmental microbial species (Sender et al …
developed symbiotically with a diversity of environmental microbial species (Sender et al …
Gamma-aminobutyric acid signaling in damage response, metabolism, and disease
K Kim, H Yoon - International Journal of Molecular Sciences, 2023 - mdpi.com
Gamma-aminobutyric acid (GABA) plays a crucial role in signal transduction and can
function as a neurotransmitter. Although many studies have been conducted on GABA in …
function as a neurotransmitter. Although many studies have been conducted on GABA in …
Dietary fiber modulates the release of gut bacterial products preventing cognitive decline in an Alzheimer's mouse model
Fiber intake is associated with a lower risk for Alzheimer´ s disease (AD) in older adults.
Intake of plant-based diets rich in soluble fiber promotes the production of short-chain fatty …
Intake of plant-based diets rich in soluble fiber promotes the production of short-chain fatty …
Imaging brain glucose metabolism in vivo reveals propionate as a major anaplerotic substrate in pyruvate dehydrogenase deficiency
I Marin-Valencia, A Kocabas, C Rodriguez-Navas… - Cell metabolism, 2024 - cell.com
A vexing problem in mitochondrial medicine is our limited capacity to evaluate the extent of
brain disease in vivo. This limitation has hindered our understanding of the mechanisms that …
brain disease in vivo. This limitation has hindered our understanding of the mechanisms that …
Propionate and Alzheimer's disease
J Killingsworth, D Sawmiller, RD Shytle - Frontiers in aging …, 2021 - frontiersin.org
Propionate, a short-chain fatty acid, serves important roles in the human body. However, our
review of the current literature suggests that under certain conditions, excess levels of …
review of the current literature suggests that under certain conditions, excess levels of …
Human forebrain organoid-based multi-omics analyses of PCCB as a schizophrenia associated gene linked to GABAergic pathways
W Zhang, M Zhang, Z Xu, H Yan, H Wang… - Nature …, 2023 - nature.com
Identifying genes whose expression is associated with schizophrenia (SCZ) risk by
transcriptome-wide association studies (TWAS) facilitates downstream experimental studies …
transcriptome-wide association studies (TWAS) facilitates downstream experimental studies …
Central and peripheral regulations mediated by short-chain fatty acids on energy homeostasis
The human gut microbiota influences obesity, insulin resistance, and the subsequent
development of type 2 diabetes (T2D). The gut microbiota digests and ferments nutrients …
development of type 2 diabetes (T2D). The gut microbiota digests and ferments nutrients …
Ifosfamide-History, efficacy, toxicity and encephalopathy
In this review we trace the passage of fundamental ideas through 20 th century cancer
research that began with observations on mustard gas toxicity in World War I. The …
research that began with observations on mustard gas toxicity in World War I. The …
Antibiotics and the develo** intestinal microbiome, metabolome and inflammatory environment in a randomized trial of preterm infants
Antibiotic use in neonates can have detrimental effects on the develo** gut microbiome,
increasing the risk of morbidity. A majority of preterm neonates receive antibiotics after birth …
increasing the risk of morbidity. A majority of preterm neonates receive antibiotics after birth …
Pathophysiological mechanisms of complications associated with propionic acidemia
Propionic acidemia (PA) is a genetic metabolic disorder caused by mutations in the
mitochondrial enzyme, propionyl-CoA carboxylase (PCC), which is responsible for …
mitochondrial enzyme, propionyl-CoA carboxylase (PCC), which is responsible for …