Since the discovery of sickle cell disease (SCD) in 1910, enormous strides have been made
in the elucidation of the pathogenesis of its protean complications, which has inspired recent …

The selectins are transmembrane, Ca2+-dependent lectins that mediate leucocyte rolling on
vascular surfaces, the first adhesive step during inflammation and immune surveillance …

Background The up-regulation of P-selectin in endothelial cells and platelets contributes to
the cell–cell interactions that are involved in the pathogenesis of vaso-occlusion and sickle …

Neutrophil extracellular traps (NETs) can be released in the vasculature. In addition to
trap** microbes, they promote inflammatory and thrombotic diseases. Considering that P …

Nucleic acids are the foundation of life. Specific sequences translate certain genetic traits,
protein expression, and, ultimately, cellular function. Yet, nucleic acids not only store genetic …

Recurrent and unpredictable episodes of vaso-occlusion are the hallmark of sickle cell
disease. Symptomatic management and prevention of these events using the fetal …

The primary β-globin gene mutation that causes sickle cell disease (SCD) has significant
pathophysiological consequences that result in hemolytic events and the induction of the …

For over 100 years, clinicians and scientists have been unravelling the consequences of the
A to T substitution in the β-globin gene that produces haemoglobin S, which leads to the …

Anemia is a major source of morbidity and mortality worldwide. Here we review recent
insights into how red blood cells (RBCs) are produced, the pathogenic mechanisms …

Persistent inflammation within atherosclerotic plaques is a crucial factor contributing to
plaque vulnerability and rupture. It has become increasingly evident that the …