Skeletal infections: microbial pathogenesis, immunity and clinical management

EA Masters, BF Ricciardi, KLM Bentley… - Nature Reviews …, 2022 - nature.com
Osteomyelitis remains one of the greatest risks in orthopaedic surgery. Although many
organisms are linked to skeletal infections, Staphylococcus aureus remains the most …

Pathogenicity and virulence of Staphylococcus aureus

GYC Cheung, JS Bae, M Otto - Virulence, 2021 - Taylor & Francis
Staphylococcus aureus is one of the most frequent worldwide causes of morbidity and
mortality due to an infectious agent. This pathogen can cause a wide variety of diseases …

Staphylococcus aureus Secreted Toxins and Extracellular Enzymes

K Tam, VJ Torres - Microbiology spectrum, 2019 - Am Soc Microbiol
Staphylococcus aureus is a formidable pathogen capable of causing infections in different
sites of the body in a variety of vertebrate animals, including humans and livestock. A major …

Clinical Impact of Staphylococcus aureus Skin and Soft Tissue Infections

MS Linz, A Mattappallil, D Finkel, D Parker - Antibiotics, 2023 - mdpi.com
The pathogenic bacterium Staphylococcus aureus is the most common pathogen isolated in
skin-and-soft-tissue infections (SSTIs) in the United States. Most S. aureus SSTIs are caused …

Staphylococcal manipulation of host immune responses

V Thammavongsa, HK Kim, D Missiakas… - Nature Reviews …, 2015 - nature.com
Staphylococcus aureus, a bacterial commensal of the human nares and skin, is a frequent
cause of soft tissue and bloodstream infections. A hallmark of staphylococcal infections is …

Pathogenesis of Staphylococcus aureus Bloodstream Infections

L Thomer, O Schneewind… - Annual Review of …, 2016 - annualreviews.org
Staphylococcus aureus, a Gram-positive bacterium colonizing nares, skin, and the
gastrointestinal tract, frequently invades the skin, soft tissues, and bloodstreams of humans …

Staphylococcus aureus Colonization: Modulation of Host Immune Response and Impact on Human Vaccine Design

AF Brown, JM Leech, TR Rogers… - Frontiers in …, 2014 - frontiersin.org
In apparent contrast to its invasive potential Staphylococcus aureus colonizes the anterior
nares of 20–80% of the human population. The relationship between host and microbe …

Staphylococcus aureus

TJ Foster - Molecular medical microbiology, 2002 - Elsevier
Publisher Summary The natural habitat of Staphylococcus aureus in humans is the skin and
nasopharynx. It can cause a wide variety of infections involving skin and soft tissues …

Mechanisms of Immune Evasion and Bone Tissue Colonization That Make Staphylococcus aureus the Primary Pathogen in Osteomyelitis

G Muthukrishnan, EA Masters, JL Daiss… - Current osteoporosis …, 2019 - Springer
Abstract Purpose of Review Staphylococcus aureus is the primary pathogen responsible for
osteomyelitis, which remains a major healthcare burden. To understand its dominance, here …

Contribution of Coagulases towards Staphylococcus aureus Disease and Protective Immunity

AG Cheng, M McAdow, HK Kim, T Bae… - PLoS …, 2010 - journals.plos.org
The bacterial pathogen Staphylococcus aureus seeds abscesses in host tissues to replicate
at the center of these lesions, protected from host immune cells via a pseudocapsule. Using …