Type 1 diabetes mellitus is believed to result from destruction of the insulin-producing β-cells
in pancreatic islets that is mediated by autoimmune mechanisms. The classic view is that …

Loss of functional β-cell mass is the key mechanism leading to the two main forms of
diabetes mellitus—type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) …

Summary Type 1 diabetes (T1D) is widely considered to result from the autoimmune
destruction of insulin-producing β cells. This concept has been a central tenet for decades of …

Type 1 diabetes (T1D) is a multifactorial autoimmune disease driven by T-cells against the
insulin-producing islet β-cells, resulting in a marked loss of β-cell mass and function …

Abstract Purpose of Review To discuss the current understanding of “β cell identity” and
factors underlying altered identity of pancreatic β cells in diabetes, especially in humans …

Background Previous studies of type 1 diabetes in childhood and adolescence have found
large variations in reported incidence around the world. However, it is unclear whether these …

Abstract Type 2 diabetes (T2D) is a global health problem characterised by chronic
hyperglycaemia due to inadequate insulin secretion. Because glucose must be metabolised …

Pancreatic islets consist of multiple cell types that produce hormones required for glucose
homeostasis, and islet dysfunction is a major factor in type 1 and type 2 diabetes. Numerous …

Diabetes Mellitus is a group of diseases characterized by high blood glucose levels due to
patients' inability to produce sufficient insulin. Current interventions often require implants …

Diabetes mellitus is etiologically classified into type 1, type 2 and other types of diabetes.
Despite distinct etiologies and pathogenesis of these subtypes, many studies have …