Surmounting cancer drug resistance: New insights from the perspective of N6-methyladenosine RNA modification
Despite the development of targeted therapy, drug resistance remains a primary hindrance
to curative treatment of various cancers. Among several novel approaches to overcome drug …
to curative treatment of various cancers. Among several novel approaches to overcome drug …
Targeting RNA N6-methyladenosine to synergize with immune checkpoint therapy
X Zhou, C Li, T Chen, W Li, X Wang, Q Yang - Molecular Cancer, 2023 - Springer
Cancer immunotherapy, especially immune checkpoint therapy, has revolutionized
therapeutic options by reactivating the host immune system. However, the efficacy varies …
therapeutic options by reactivating the host immune system. However, the efficacy varies …
The m6A RNA demethylase ALKBH5 promotes radioresistance and invasion capability of glioma stem cells
A Kowalski-Chauvel, MG Lacore, F Arnauduc… - Cancers, 2020 - mdpi.com
Simple Summary Glioblastoma stem cells (GBMSCs), which are particularly radio-resistant
and invasive, are responsible for the high recurrence of glioblastoma (GBM). Therefore …
and invasive, are responsible for the high recurrence of glioblastoma (GBM). Therefore …
Repositioning of anti-inflammatory drugs for the treatment of cervical cancer sub-types
Cervical cancer is the fourth most commonly diagnosed cancer worldwide and, in almost all
cases is caused by infection with highly oncogenic Human Papillomaviruses (HPVs). On the …
cases is caused by infection with highly oncogenic Human Papillomaviruses (HPVs). On the …
The Interaction of Human Papillomavirus Infection and Prostaglandin E2 Signaling in Carcinogenesis: A Focus on Cervical Cancer Therapeutics
J García-Quiroz, B Vázquez-Almazán… - Cells, 2022 - mdpi.com
Chronic infection by high-risk human papillomaviruses (HPV) and chronic inflammation are
factors associated with the onset and progression of several neoplasias, including cervical …
factors associated with the onset and progression of several neoplasias, including cervical …
Proteomics analysis of meclofenamic acid‐treated small cell lung carcinoma cells revealed changes in cellular energy metabolism for cancer cell survival
Small cell lung carcinoma (SCLC) is a highly aggressive cancer with low survival rate.
Although initial response to chemotherapy in SCLC patients is well‐rated, the treatments …
Although initial response to chemotherapy in SCLC patients is well‐rated, the treatments …
Fenamates: Forgotten treasure for cancer treatment and prevention: Mechanisms of action, structural modification, and bright future
Fenamates as classical nonsteroidal anti‐inflammatory agents are widely used for relieving
pain. Preclinical studies and epidemiological data highlight their chemo‐preventive and …
pain. Preclinical studies and epidemiological data highlight their chemo‐preventive and …
Advances in molecular mechanism of HPV16 E5 oncoprotein carcinogenesis
B Chen, L Zhao, R Yang, T Xu - Archives of Biochemistry and Biophysics, 2023 - Elsevier
For a considerable duration, cervical cancer has posed a significant risk to the well-being
and survival of women. The emergence and progression of cervical cancer have garnered …
and survival of women. The emergence and progression of cervical cancer have garnered …
Niosomal formulation of mefenamic acid for enhanced cancer targeting; preparation, characterization and biodistribution study using radiolabeling technique
Background This work aimed to prepare niosomal formulations of an anticancer agent
[mefenamic acid (MEF)] to enhance its cancer targeting. 131I was utilized as a radiolabeling …
[mefenamic acid (MEF)] to enhance its cancer targeting. 131I was utilized as a radiolabeling …
Two isostructural Co (II) flufenamato and niflumato complexes with bathocuproine: Analogues with a different cytotoxic activity
L Smolko, R Smolková, E Samoľová, I Morgan… - Journal of Inorganic …, 2020 - Elsevier
Two novel Co (II) fenamato complexes containing bathocuproine (bcp), namely [Co
(bcp)(flu) 2](1) and [Co (bcp)(nif) 2](2)(flu= flufenamato, nif= niflumato) were synthesized and …
(bcp)(flu) 2](1) and [Co (bcp)(nif) 2](2)(flu= flufenamato, nif= niflumato) were synthesized and …