Aberrant skip** of coding exons in CD19 and CD22 compromises the response to
immunotherapy in B-cell malignancies. Here, we showed that the MS4A1 gene encoding …

The identification of targetable vulnerabilities in the context of therapeutic resistance is a key
challenge in cancer treatment. We detected pervasive aberrant splicing as a characteristic …

The discovery of new genes/pathways improves our knowledge of cancer pathogenesis and
presents novel potential therapeutic options. For instance, splicing factor 3b subunit 1 …

Acute myeloid leukemia (AML) is a devastating cancer affecting the hematopoietic system.
Previous research has relied on RNA sequencing and microarray techniques to study the …

Coordination of a number of molecular mechanisms including transcription, alternative
splicing, and class switch recombination are required to facilitate development, activation …

Genes encoding the RNA splicing factors SF3B1, SRSF2, and U2AF1 are subject to frequent
missense mutations in clonal hematopoiesis and diverse neoplastic diseases. Most …

Background Splicing factor 3b subunit 1 (SF3B1), a splicing factor modulating RNA
alternative splicing, is frequently mutated in multiple hematological malignancies including …

Cancer-associated mutations of the core splicing factor 3 B1 (SF3B1) result in selection of
novel 3′ splice sites (3′ SS), but precise molecular mechanisms of oncogenesis remain …

At the end of introns, the polypyrimidine tract (Py) is often close to the 3′ AG in a consensus
(Y) 20NC AG gt in humans. Interestingly, we have found that they could also be separated …

In order to survive to the exposure of DNA damaging agents, cells activate a complex
response that coordinates the cellular metabolism, cell cycle progression, and DNA repair …