NADPH oxidases: an overview from structure to innate immunity-associated pathologies

A Panday, MK Sahoo, D Osorio, S Batra - Cellular & molecular …, 2015 - nature.com
Oxygen-derived free radicals, collectively termed reactive oxygen species (ROS), play
important roles in immunity, cell growth, and cell signaling. In excess, however, ROS are …

[HTML][HTML] Unlocking the power of NOX2: a comprehensive review on its role in immune regulation

K Bode, M Hauri-Hohl, V Jaquet, H Weyd - Redox biology, 2023 - Elsevier
Reactive oxygen species (ROS) are a family of highly reactive molecules with numerous,
often pleiotropic functions within the cell and the organism. Due to their potential to destroy …

Sex-related differences in oxidative stress and neurodegeneration

MA Tenkorang, B Snyder, RL Cunningham - Steroids, 2018 - Elsevier
Oxidative stress has been implicated in a number of neurodegenerative diseases spanning
various fields of research. Reactive oxygen species can be beneficial or harmful, depending …

The metabolic enzyme fructose-1,6-bisphosphate aldolase acts as a transcriptional regulator in pathogenic Francisella

J Ziveri, F Tros, IC Guerrera, C Chhuon, M Audry… - Nature …, 2017 - nature.com
The enzyme fructose-bisphosphate aldolase occupies a central position in glycolysis and
gluconeogenesis pathways. Beyond its housekee** role in metabolism, fructose …

The multi-faceted role of NADPH in regulating inflammation in activated myeloid cells

KKY Ting, J Jongstra-Bilen, MI Cybulsky - Frontiers in Immunology, 2023 - frontiersin.org
Recent advances in the immunometabolism field have demonstrated the importance of
metabolites in fine-tuning the inflammatory responses in myeloid cells. Cofactors, which are …

[HTML][HTML] Xanthine oxidase-lactoperoxidase system and innate immunity: Biochemical actions and physiological roles

SS Al-Shehri, JA Duley, N Bansal - Redox biology, 2020 - Elsevier
The innate immune system in mammals is the first-line defense that plays an important
protective role against a wide spectrum of pathogens, especially during early life before the …

[HTML][HTML] Macrophages in oxidative stress and models to evaluate the antioxidant function of dietary natural compounds

OA Castaneda, SC Lee, CT Ho, TC Huang - journal of food and drug …, 2017 - Elsevier
Antioxidant testing of natural products has attracted increasing interest in recent years,
mainly due to the fact that an antioxidant-rich diet might provide health benefits. Activated …

The urotensin II receptor triggers an early meningeal response and a delayed macrophage-dependent vasospasm after subarachnoid hemorrhage in male mice

M Pedard, L Prevost, C Carpena, B Holleran… - Nature …, 2024 - nature.com
Subarachnoid hemorrhage (SAH) can be associated with neurological deficits and has
profound consequences for mortality and morbidity. Cerebral vasospasm (CVS) and …

Hybrid Hydrogel with Photothermal Stimulation Elicits Immunomodulation‐Mediated Wound Healing

R Zhang, J Feng, H Chen, G Zhang… - Advanced Functional …, 2024 - Wiley Online Library
It is of paramount importance to maintain the thermal environment of wounds in order to
facilitate optimal tissue repair and regeneration. Nevertheless, their potential as a …

[HTML][HTML] Systematic evaluation of transcriptomic disease risk and diagnostic biomarker overlap between COVID-19 and tuberculosis: a patient-level meta-analysis

D Sheerin, X Wang, WE Johnson, A Coussens - MedRxiv, 2020 - ncbi.nlm.nih.gov
Background The novel coronavirus, SARS-CoV-2, has increased the burden on healthcare
systems already strained by a high incidence of tuberculosis (TB) as co-infection and dual …