Astrocyte morphology

KT Baldwin, KK Murai, BS Khakh - Trends in cell biology, 2024 - cell.com
Astrocytes are predominant glial cells that tile the central nervous system (CNS). A cardinal
feature of astrocytes is their complex and visually enchanting morphology, referred to as …

Astrocyte endfeet in brain function and pathology: open questions

B Díaz-Castro, S Robel, A Mishra - Annual Review of …, 2023 - annualreviews.org
Astrocyte endfeet enwrap the entire vascular tree within the central nervous system, where
they perform important functions in regulating the blood-brain barrier (BBB), cerebral blood …

Beyond the GFAP-astrocyte protein markers in the brain

AM Jurga, M Paleczna, J Kadluczka, KZ Kuter - Biomolecules, 2021 - mdpi.com
The idea of central nervous system as one-man band favoring neurons is long gone. Now
we all are aware that neurons and neuroglia are team players and constant communication …

[HTML][HTML] Cell biology of astrocyte-synapse interactions

NJ Allen, C Eroglu - Neuron, 2017 - cell.com
Astrocytes, the most abundant glial cells in the mammalian brain, are critical regulators of
brain development and physiology through dynamic and often bidirectional interactions with …

Astrocytes, neurons, synapses: a tripartite view on cortical circuit development

I Farhy-Tselnicker, NJ Allen - Neural development, 2018 - Springer
In the mammalian cerebral cortex neurons are arranged in specific layers and form
connections both within the cortex and with other brain regions, thus forming a complex …

Diversity of astrocyte functions and phenotypes in neural circuits

BS Khakh, MV Sofroniew - Nature neuroscience, 2015 - nature.com
Astrocytes tile the entire CNS. They are vital for neural circuit function, but have traditionally
been viewed as simple, homogenous cells that serve the same essential supportive roles …

Improved tools to study astrocytes

X Yu, J Nagai, BS Khakh - Nature Reviews Neuroscience, 2020 - nature.com
Astrocytes are a type of glial cell that tile the CNS. They interact with multiple cell types,
including neurons, glial cells and blood vessels, and are involved or implicated in brain …

Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system

EM Hol, M Pekny - Current opinion in cell biology, 2015 - Elsevier
Glial fibrillary acidic protein (GFAP) is the hallmark intermediate filament (IF; also known as
nanofilament) protein in astrocytes, a main type of glial cells in the central nervous system …

Astrocyte reactivity and reactive astrogliosis: costs and benefits

M Pekny, M Pekna - Physiological reviews, 2014 - journals.physiology.org
Astrocytes are the most abundant cells in the central nervous system (CNS) that provide
nutrients, recycle neurotransmitters, as well as fulfill a wide range of other homeostasis …

The dual role of astrocyte activation and reactive gliosis

M Pekny, U Wilhelmsson, M Pekna - Neuroscience letters, 2014 - Elsevier
Astrocyte activation and reactive gliosis accompany most of the pathologies in the brain,
spinal cord, and retina. Reactive gliosis has been described as constitutive, graded, multi …