Toward a better understanding of the atypical features of chronic graft-versus-host disease: a report from the 2020 National Institutes of Health Consensus Project …

GDE Cuvelier, M Schoettler, NP Buxbaum… - … and cellular therapy, 2022 - Elsevier
Alloreactive and autoimmune responses after allogeneic hematopoietic cell transplantation
can occur in nonclassical chronic graft-versus-host disease (chronic GVHD) tissues and …

Neurodegeneration in multiple sclerosis

GM Mey, KR Mahajan… - WIREs mechanisms of …, 2023 - Wiley Online Library
Axonal loss in multiple sclerosis (MS) is a key component of disease progression and
permanent neurologic disability. MS is a heterogeneous demyelinating and …

Proteomics reveal biomarkers for diagnosis, disease activity and long-term disability outcomes in multiple sclerosis

J Åkesson, S Hojjati, S Hellberg, J Raffetseder… - Nature …, 2023 - nature.com
Sensitive and reliable protein biomarkers are needed to predict disease trajectory and
personalize treatment strategies for multiple sclerosis (MS). Here, we use the highly …

Serum neurofilament light chain measurement in MS: hurdles to clinical translation

S Thebault, RA Booth, CA Rush, H MacLean… - Frontiers in …, 2021 - frontiersin.org
Measurement of serum neurofilament light chain concentration (sNfL) promises to become a
convenient, cost effective and meaningful adjunct for multiple sclerosis (MS) prognostication …

Association of serum neurofilament light chain levels at disease onset with disability worsening in patients with a first demyelinating multiple sclerosis event not treated …

E Monreal, JI Fernández-Velasco… - JAMA …, 2023 - jamanetwork.com
Importance The value of serum neurofilament light chain (sNfL) levels for predicting long-
term disability in patients with multiple sclerosis (MS) remains controversial. Objective To …

[HTML][HTML] Neurodegeneration in multiple sclerosis: Symptoms of silent progression, biomarkers and neuroprotective therapy—Kynurenines are important players

D Sandi, Z Fricska-Nagy, K Bencsik, L Vécsei - Molecules, 2021 - mdpi.com
Neurodegeneration is one of the driving forces behind the pathogenesis of multiple sclerosis
(MS). Progression without activity, pathopsychological disturbances (cognitive impairment …

[HTML][HTML] High or increasing serum NfL is predictive of impending multiple sclerosis relapses

S Thebault, M Reaume, RA Marrie, JJ Marriott… - Multiple sclerosis and …, 2022 - Elsevier
Background One-off serum levels of neurofilament light chain (sNfL) is an established
predictor of emerging disease activity in multiple sclerosis (MS). However, the importance of …

Validity of serum neurofilament light chain as a prognostic biomarker of disease activity in multiple sclerosis

MK Sen, MJ Hossain, DA Mahns, BJ Brew - Journal of Neurology, 2023 - Springer
Multiple sclerosis (MS) is a chronic demyelinating and neuroinflammatory disease of the
human central nervous system with complex pathoetiology, heterogeneous presentations …

Serum biomarkers at disease onset for personalized therapy in multiple sclerosis

E Monreal, JI Fernández-Velasco, R Álvarez-Lafuente… - Brain, 2024 - academic.oup.com
The potential for combining serum neurofilament light chain (sNfL) and glial fibrillary acidic
protein (sGFAP) levels to predict worsening disability in multiple sclerosis remains …