The sleep-immune crosstalk in health and disease

L Besedovsky, T Lange, M Haack - Physiological reviews, 2019 - journals.physiology.org
Sleep-immune interactions are well-known phenomena in everyday life and folk wisdom.
There is no doubt that an infection makes us tired and increases the desire to sleep, and a …

Sleep and inflammation: partners in sickness and in health

MR Irwin - Nature Reviews Immunology, 2019 - nature.com
The discovery of reciprocal connections between the central nervous system, sleep and the
immune system has shown that sleep enhances immune defences and that afferent signals …

Circadian rhythms and cancers: the intrinsic links and therapeutic potentials

L Zhou, Z Zhang, E Nice, C Huang, W Zhang… - Journal of hematology & …, 2022 - Springer
The circadian rhythm is an evolutionarily conserved time-kee** system that comprises a
wide variety of processes including sleep–wake cycles, eating–fasting cycles, and activity …

Interleukin-6 signaling pathway and its role in kidney disease: an update

H Su, CT Lei, C Zhang - Frontiers in immunology, 2017 - frontiersin.org
Interleukin-6 (IL-6) is a pleiotropic cytokine that not only regulates the immune and
inflammatory response but also affects hematopoiesis, metabolism, and organ development …

[HTML][HTML] Role of IL-6 in the regulation of neuronal development, survival and function

KK Kummer, M Zeidler, T Kalpachidou, M Kress - Cytokine, 2021 - Elsevier
The pleiotropic cytokine interleukin-6 (IL-6) is emerging as a molecule with both beneficial
and destructive potentials. It can exert opposing actions triggering either neuron survival …

Interleukin-6 as potential mediator of long-term neuropsychiatric symptoms of COVID-19

N Kappelmann, R Dantzer, GM Khandaker - Psychoneuroendocrinology, 2021 - Elsevier
The majority of COVID-19 survivors experience long-term neuropsychiatric symptoms such
as fatigue, slee** difficulties, depression and anxiety. We propose that neuroimmune …

Sleep health: reciprocal regulation of sleep and innate immunity

MR Irwin, MR Opp - Neuropsychopharmacology, 2017 - nature.com
Sleep disturbances including insomnia independently contribute to risk of inflammatory
disorders and major depressive disorder. This review and overview provides an integrated …

Role of interleukin-6-mediated inflammation in the pathogenesis of inflammatory bowel disease: focus on the available therapeutic approaches and gut microbiome

A Shahini, A Shahini - Journal of cell communication and signaling, 2023 - Springer
Inflammatory bowel disease (IBD) is considered a chronic inflammatory and multifactorial
disease of the gastrointestinal tract. Crohn's disease (CD) and ulcerative colitis (UC) are two …

[HTML][HTML] The role of interleukin-6 signaling in nervous tissue

M Rothaug, C Becker-Pauly, S Rose-John - Biochimica et Biophysica Acta …, 2016 - Elsevier
Abstract The cytokine interleukin-6 (IL-6) plays a critical role in the pathogenesis of
inflammatory disorders and in the physiological homeostasis of neural tissue. Profound …

Interleukin-6: Biology, signaling and strategies of blockade

F Schaper, S Rose-John - Cytokine & growth factor reviews, 2015 - Elsevier
Abstract Interleukin-6 (IL-6) is one of the most important inflammatory cytokines. IL-6 is
unique in signaling via a membrane bound and a soluble receptor. Intriguingly, these two …