To understand the placement of a certain protein in a physiological system and the
pathogenesis of related disorders, it is not only of interest to determine its function but also …

Abstract Weibel-Palade bodies (WPBs) are elongated secretory organelles specific to
endothelial cells that contain von Willebrand factor (VWF) and a variety of other proteins that …

The blood vessel wall has a number of self‐healing properties, enabling it to minimize blood
loss and prevent or overcome infections in the event of vascular trauma. Endothelial cells …

This review summarizes recently published data on the mechanisms of tumor cell interaction
with the tumor microenvironment. Tumor stroma influences the processes of …

The vascular environment can rapidly alter, and the speed with which responses to both
physiological and pathological changes are required necessitates the existence of a highly …

The von Willebrand factor (VWF) synthesized and secreted by endothelial cells is central to
hemostasis and thrombosis, providing a multifunctional adhesive platform that brings …

Endothelium is strategically located at the interface between blood and interstitial tissues,
placing thus endothelial cell as a key player in vascular homeostasis. Endothelial cells are …

The endothelium plays a crucial role in inflammation. A balanced control of inflammation
requires the action of glucocorticoids (GCs), steroidal hormones with potent cell-specific anti …

The making and breaking of clots orchestrated by the thrombotic and thrombolytic serine
protease cascades are critical determinants of morbidity and mortality during infection and …

Vascular endothelial cells contain unique storage organelles, designated Weibel-Palade
bodies (WPBs), that deliver inflammatory and hemostatic mediators to the vascular lumen in …