Recent advances in the label-free characterization of exosomes for cancer liquid biopsy: from scattering and spectroscopy to nanoindentation and nanodevices

R Di Santo, S Romanò, A Mazzini, S Jovanović… - Nanomaterials, 2021 - mdpi.com
Exosomes (EXOs) are nano-sized vesicles secreted by most cell types. They are abundant
in bio-fluids and harbor specific molecular constituents from their parental cells. Due to these …

Estimates of natural frequencies for nuclear vibration, and an assessment of the feasibility of selective ultrasound ablation of cancer cells

B Qi, H Zhang, J Zhu, M Wang, C Ma, GM Genin… - Journal of the …, 2024 - Elsevier
Selective ablation of cancer cells by ultrasound would be transformative for cancer therapy,
but has not yet been possible. A key challenge is that cancerous and non-cancerous cells …

Mechanical Properties of the Extracellular Environment of Human Brain Cells Drive the Effectiveness of Drugs in Fighting Central Nervous System Cancers

M Cieśluk, K Pogoda, E Piktel, U Wnorowska… - Brain Sciences, 2022 - mdpi.com
The evaluation of nanomechanical properties of tissues in health and disease is of
increasing interest to scientists. It has been confirmed that these properties, determined in …

Sensing red blood cell nano-mechanics: Toward a novel blood biomarker for Alzheimer's disease

M Nardini, G Ciasca, A Lauria, C Rossi… - Frontiers in Aging …, 2022 - frontiersin.org
Red blood cells (RBCs) are characterized by a remarkable elasticity, which allows them to
undergo very large deformation when passing through small vessels and capillaries. This …

Changes in spinal cord stiffness in the course of experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis

G Pyka-Fościak, J Zemła, GJ Lis, JA Litwin… - Archives of biochemistry …, 2020 - Elsevier
Experimental autoimmune encephalomyelitis (EAE) is a commonly used mouse model of
multiple sclerosis, a chronic inflammatory disease of the central nervous system (CNS) …

A novel method for post-mortem interval estimation based on tissue nano-mechanics

F De-Giorgio, M Nardini, F Foti, E Minelli… - International journal of …, 2019 - Springer
Forensic estimation of post-mortem interval relies on different methods, most of which,
however, have practical limitations or provide insufficient results, still lacking a gold standard …

Dynamic structural determinants underlie the neurotoxicity of the N-terminal tau 26-44 peptide in Alzheimer's disease and other human tauopathies

G Perini, G Ciasca, E Minelli, M Papi, V Palmieri… - International journal of …, 2019 - Elsevier
The intrinsically disordered tau protein plays a pivotal role in the pathogenesis of
Alzheimer's disease (AD) and other human tauopathies. Abnormal post-translational …

Efficient spatial sampling for AFM-based cancer diagnostics: a comparison between neural networks and conventional data analysis

G Ciasca, A Mazzini, TE Sassun, M Nardini, E Minelli… - Condensed …, 2019 - mdpi.com
Atomic force microscopy (AFM) in spectroscopy mode receives a lot of attention because of
its potential in distinguishing between healthy and cancer tissues. However, the AFM …

An evaluation of the objectivity and reproducibility of shear wave elastography in estimating the post-mortem interval: a tissue biomechanical perspective

F De-Giorgio, G Ciasca, R D'Amico… - International Journal of …, 2020 - Springer
Cadaveric rigidity—also referred to as rigor mortis—is a valuable source of information for
estimating the time of death, which is a fundamental and challenging task in forensic …

[HTML][HTML] Sensing Biomechanical Alterations in Red Blood Cells of Type 1 Diabetes Patients: Potential Markers for Microvascular Complications

R Di Santo, B Niccolini, A Rizzi, L Bertini, DP Marafon… - Biosensors, 2024 - mdpi.com
In physiological conditions, red blood cells (RBCs) demonstrate remarkable deformability,
allowing them to undergo considerable deformation when passing through the …