Drug delivery to the central nervous system
Despite the rising global incidence of central nervous system (CNS) disorders, CNS drug
development remains challenging, with high costs, long pathways to clinical use and high …
development remains challenging, with high costs, long pathways to clinical use and high …
Recent progress on polysaccharide-based hydrogels for controlled delivery of therapeutic biomolecules
A plethora of applications using polysaccharides have been developed in recent years due
to their availability as well as their frequent nontoxicity and biodegradability. These polymers …
to their availability as well as their frequent nontoxicity and biodegradability. These polymers …
Recent advance in delivery system and tissue engineering applications of chondroitin sulfate
Chondroitin sulfate (CS) is a naturally derived bioactive macromolecule and the major
component of extracellular matrix (ECM), which widely distributed in various organisms and …
component of extracellular matrix (ECM), which widely distributed in various organisms and …
Heparin-mediated delivery of bone morphogenetic protein-2 improves spatial localization of bone regeneration
Supraphysiologic doses of bone morphogenetic protein-2 (BMP-2) are used clinically to
promote bone formation in fracture nonunions, large bone defects, and spinal fusion …
promote bone formation in fracture nonunions, large bone defects, and spinal fusion …
Self-assembling peptide hydrogels for the stabilization and sustained release of active Chondroitinase ABC in vitro and in spinal cord injuries
Activated microglia/macrophages infiltration, astrocyte migration, and increased production
of inhibitory chondroitin sulfate proteoglycans (CSPGs) are standard harmful events taking …
of inhibitory chondroitin sulfate proteoglycans (CSPGs) are standard harmful events taking …
Inhibition of CSPG receptor PTPσ promotes migration of newly born neuroblasts, axonal sprouting, and recovery from stroke
F Luo, J Wang, Z Zhang, Z You, A Bedolla… - Cell reports, 2022 - cell.com
In addition to neuroprotective strategies, neuroregenerative processes could provide targets
for stroke recovery. However, the upregulation of inhibitory chondroitin sulfate proteoglycans …
for stroke recovery. However, the upregulation of inhibitory chondroitin sulfate proteoglycans …
[HTML][HTML] The extracellular matrix as modifier of neuroinflammation and recovery in ischemic stroke and intracerebral hemorrhage
Stroke is the second leading cause of death worldwide and has two major subtypes:
ischemic stroke and hemorrhagic stroke. Neuroinflammation is a pathological hallmark of …
ischemic stroke and hemorrhagic stroke. Neuroinflammation is a pathological hallmark of …
[HTML][HTML] Multiscale design of stiffening and ROS scavenging hydrogels for the augmentation of mandibular bone regeneration
Y Wu, X Li, Y Sun, X Tan, C Wang, Z Wang, L Ye - Bioactive Materials, 2023 - Elsevier
Although biomimetic hydrogels play an essential role in guiding bone remodeling,
reconstructing large bone defects is still a significant challenge since bioinspired gels often …
reconstructing large bone defects is still a significant challenge since bioinspired gels often …
Recent advances in the therapeutic uses of chondroitinase ABC
E Muir, F De Winter, J Verhaagen, J Fawcett - Experimental neurology, 2019 - Elsevier
Many studies, using pre-clinical models of SCI, have demonstrated the efficacy of
chondroitinase ABC as a treatment for spinal cord injury and this has been confirmed in …
chondroitinase ABC as a treatment for spinal cord injury and this has been confirmed in …
Engineering hydrogels for affinity-based release of therapeutic proteins
Therapeutic proteins can treat a myriad of diseases; however, their effectiveness is limited
by short half-lives. Controlled release systems are advantageous because they prolong the …
by short half-lives. Controlled release systems are advantageous because they prolong the …