Venoms are integrated phenotypes that evolved independently in, and are used for
predatory and defensive purposes by, a wide phylogenetic range of organisms. The same …

This work offers a general overview on the evolving strategies for the proteomic analysis of
snake venoms, and discusses how these may be combined through diverse experimental …

Variation in venom composition is a ubiquitous phenomenon in snakes and occurs both
interspecifically and intraspecifically. Venom variation can have severe outcomes for …

The genetic origin of novel traits is a central but challenging puzzle in evolutionary biology.
Among snakes, phospholipase A2 (PLA 2)-related toxins have evolved in different lineages …

Snake venoms represent a danger to human health, but also a gold mine of bioactive
proteins that can be harnessed for drug discovery purposes. The evolution of snakes and …

Variation in gene regulation is ubiquitous, yet identifying the mechanisms producing such
variation, especially for complex traits, is challenging. Snake venoms provide a model …

The snake is the symbol of medicine due to its association with Asclepius, the Greek God of
medicine, and so with good reasons. More than 725 species of venomous snakes have …

Snake venoms present a great diversity of pharmacologically active compounds that may be
applied as research and biotechnological tools, as well as in drug development and …

We report on the first application of top-down mass spectrometry in snake venomics. De
novo sequence tags generated by, and ProSight Lite supported analysis of, combined …

Venom research has been continuously enhanced by technological advances. High-
throughput technologies are changing the classical paradigm of hypothesis-driven research …