Pharmacogenomics of CYP2C9: Functional and Clinical Considerations†
CYP2C9 is the most abundant CYP2C subfamily enzyme in human liver and the most
important contributor from this subfamily to drug metabolism. Polymorphisms resulting in …
important contributor from this subfamily to drug metabolism. Polymorphisms resulting in …
Variability in bioavailability of small molecular tyrosine kinase inhibitors
M Herbrink, B Nuijen, JHM Schellens… - Cancer treatment reviews, 2015 - Elsevier
Small molecular tyrosine kinase inhibitors (smTKIs) are in the centre of the very quickly
expanding area of personalized chemotherapy and oral applicability thereof. The number of …
expanding area of personalized chemotherapy and oral applicability thereof. The number of …
Phenolics Profiling of Carpobrotus edulis (L.) NEBr. and Insights into Molecular Dynamics of Their Significance in Type 2 Diabetes Therapy and Its Retinopathy …
Adverse effects associated with synthetic drugs in diabetes therapy has prompted the search
for novel natural lead compounds with little or no side effects. Effects of phenolic compounds …
for novel natural lead compounds with little or no side effects. Effects of phenolic compounds …
[HTML][HTML] Investigation of in silico studies for cytochrome P450 isoforms specificity
Y Wei, L Palazzolo, OB Mariem, D Bianchi… - Computational and …, 2024 - Elsevier
Abstract Cytochrome P450 (CYP450) enzymes comprise a highly diverse superfamily of
heme-thiolate proteins that responsible for catalyzing over 90% of enzymatic reactions …
heme-thiolate proteins that responsible for catalyzing over 90% of enzymatic reactions …
Modeling of interactions between xenobiotics and cytochrome P450 (CYP) enzymes
H Raunio, M Kuusisto, RO Juvonen… - Frontiers in …, 2015 - frontiersin.org
The adverse effects to humans and environment of only few chemicals are well known.
Absorption, distribution, metabolism, and excretion (ADME) are the steps of pharmaco …
Absorption, distribution, metabolism, and excretion (ADME) are the steps of pharmaco …
Synthesis, molecular modeling, quantum mechanical calculations and ADME estimation studies of benzimidazole-oxadiazole derivatives as potent antifungal agents
In this study, a series of new 3-((5-(4-(5-substitue-1H-benz [d] imidazol-2-yl) phenyl)-1, 3, 4-
oxadiazol-2-yl) thio)-1-phenyl propane-1-on (4a-4d) derivatives has been designed and …
oxadiazol-2-yl) thio)-1-phenyl propane-1-on (4a-4d) derivatives has been designed and …
Pharmacogenomics of the cytochrome P450 2C family: impacts of amino acid variations on drug metabolism
Highlights•The interindividual variability of CYP2C members and its impact in drug
metabolism are reviewed.•Current advances in molecular modeling of CYP2C …
metabolism are reviewed.•Current advances in molecular modeling of CYP2C …
Plant phenolics ferulic acid and p-coumaric acid inhibit colorectal cancer cell proliferation through EGFR down-regulation
Background Colorectal cancer (CRC) or bowel cancer is one of the most important cancer
diseases, needing serious attention. The cell surface receptor gene human epidermal …
diseases, needing serious attention. The cell surface receptor gene human epidermal …
Emulating docking results using a deep neural network: a new perspective for virtual screening
Docking is one of the most important steps in virtual screening pipelines, and it is an
established method for examining potential interactions between ligands and receptors …
established method for examining potential interactions between ligands and receptors …
CYP2J2 molecular recognition: a new axis for therapeutic design
Cytochrome P450 (CYP) epoxygenases are a special subset of heme-containing CYP
enzymes capable of performing the epoxidation of polyunsaturated fatty acids (PUFA) and …
enzymes capable of performing the epoxidation of polyunsaturated fatty acids (PUFA) and …