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Making sense of the ageing methylome
Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …
been associated with a broad range of age-related diseases, including cardiovascular …
[HTML][HTML] A systematic review of biological, social and environmental factors associated with epigenetic clock acceleration
Aging involves a diverse set of biological changes accumulating over time that leads to
increased risk of morbidity and mortality. Epigenetic clocks are now widely used to quantify …
increased risk of morbidity and mortality. Epigenetic clocks are now widely used to quantify …
DNA methylation in newborns and maternal smoking in pregnancy: genome-wide consortium meta-analysis
Epigenetic modifications, including DNA methylation, represent a potential mechanism for
environmental impacts on human disease. Maternal smoking in pregnancy remains an …
environmental impacts on human disease. Maternal smoking in pregnancy remains an …
DNA methylation and healthy human aging
The process of aging results in a host of changes at the cellular and molecular levels, which
include senescence, telomere shortening, and changes in gene expression. Epigenetic …
include senescence, telomere shortening, and changes in gene expression. Epigenetic …
Skin changes during ageing
The skin provides the primary protection for the body against external injuries and is
essential in the maintenance of general homeostasis. During ageing, resident cells become …
essential in the maintenance of general homeostasis. During ageing, resident cells become …
Guidance for DNA methylation studies: statistical insights from the Illumina EPIC array
Background There has been a steady increase in the number of studies aiming to identify
DNA methylation differences associated with complex phenotypes. Many of the challenges …
DNA methylation differences associated with complex phenotypes. Many of the challenges …
An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation
Background Schizophrenia is a highly heritable, neuropsychiatric disorder characterized by
episodic psychosis and altered cognitive function. Despite success in identifying genetic …
episodic psychosis and altered cognitive function. Despite success in identifying genetic …
DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia
We performed a systematic analysis of blood DNA methylation profiles from 4483
participants from seven independent cohorts identifying differentially methylated positions …
participants from seven independent cohorts identifying differentially methylated positions …
The role of cigarette smoke-induced epigenetic alterations in inflammation
D Zong, X Liu, J Li, R Ouyang, P Chen - Epigenetics & Chromatin, 2019 - Springer
Background Exposure to cigarette smoke (CS) is a major threat to human health worldwide.
It is well established that smoking increases the risk of respiratory diseases, cardiovascular …
It is well established that smoking increases the risk of respiratory diseases, cardiovascular …
Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: findings from the Avon Longitudinal Study of Parents and Children …
Maternal smoking during pregnancy has been found to influence newborn DNA methylation
in genes involved in fundamental developmental processes. It is pertinent to understand the …
in genes involved in fundamental developmental processes. It is pertinent to understand the …