Arachidonic acid-derived prostaglandins not only contribute to the development of
inflammation as intercellular pro-inflammatory mediators, but also promote the excitability of …

We describe those sensations that are unpleasant, intense, or distressing as painful. Pain is
not homogeneous, however, and comprises three categories: physiological, inflammatory …

The possible involvement of p38 mitogen-activated protein kinase activation in spinal cord
and dorsal root ganglion (DRG) cells in the development of peripheral neuropathic pain has …

Pain is a sensory state resulting from complex integration of peripheral nociceptive inputs
and central processing. Pain consists of adaptive pain that is acute and beneficial for …

Neuropathic pain refers to a variety of chronic pain conditions with differing underlying
pathophysiologic mechanisms and origins. Recent studies indicate a communication …

Brief electrical stimulation enhances the regenerative ability of axotomized motor [Nix, WA,
Hopf, HC, 1983. Electrical stimulation of regenerating nerve and its effect on motor recovery …

As the biological alarm of impending or actual tissue damage, pain is essential for our
survival. However, when it is initiated and/or sustained by dysfunctional elements in the …

Extracellular signal-regulated protein kinase (ERK) is a mitogen-activated protein kinase
(MAPK) that mediates intracellular signal transduction in response to a variety of stimuli …

We examined the relation between ectopic afferent firing and tactile allodynia in the Chung
model of neuropathic pain. Transection of the L5 spinal nerve in rats triggered a sharp, four …

Damage to the nervous system can cause neuropathic pain, which is in general poorly
treated and involves mechanisms that are incompletely known. Currently available animal …