Functionalised piperidines are among the most common building blocks in natural products,
and, more interestingly, in many biologically active compounds such as anopterine …

The piperidine ring is an ubiquitous structural feature of many alkaloid natural products and
drug candidates. Watson et al. asserted that during a recent 10-year period there were …

We disclose the development of a novel series of 2-phenyl-2 H-indazole-7-carboxamides as
poly (ADP-ribose) polymerase (PARP) 1 and 2 inhibitors. This series was optimized to …

Among the different possible cyclizations leading to nitrogen-containing heterocycles,
iminium ion cyclization is a widely used process exemplified by some very famous, and old …

The first example of Pd-catalyzed, C3-selective arylation of unprotected pyridines has been
developed by employing a catalytic system consisting of Pd (OAc) 2 and 1, 10 …

3.1. Enzymatic reduction reactions via DKR 8308 3.2. Enzymatic hydrolysis and
esterification reactions via DKR 8310 3.3. Other enzymatic reactions via DKR 8312 3.4. Use …

A cobalt‐catalyzed asymmetric sequential hydroboration/isomerization/hydroboration of 2‐
aryl vinylcyclopropanes was for the first time reported for the preparation of valuable chiral 1 …

Process development of the synthesis of the orally active poly (ADP-ribose) polymerase
inhibitor niraparib is described. Two new asymmetric routes are reported, which converge …

C–H-functionalization has emerged as a powerful tool for the synthesis of heterocyclic
compounds. 1 However, with numerous C–H-bonds simultaneously available for activation …

Abstract Unprotected cis‐2, 3‐diarylpiperidines are synthesized through an unprecedented
palladium‐catalyzed cross‐coupling reaction between aryl halides and elusive endocyclic 1 …