Epigenetic modifications and regulators represent potential molecular elements which
control relevant physiological and pathological features, thereby contributing to the natural …

Oxidative stress is an imbalance between production and accumulation of oxygen reactive
species and/or reactive nitrogen species in cells and tissues, and the capacity of detoxifying …

As a common disease of cows occurring during their perinatal period, endometritis is known
to affect fertility. At present, the studies on endometritis mainly focus on preventing microbial …

Background Limb-girdle muscular dystrophy (LGMD) is a rare neuromuscular disease
including a growing and heterogeneous number of subtypes with variable phenotype. Their …

Friedreich's ataxia (FRDA) is a genetic neurodegenerative disease that is caused by
guanine-adenine-adenine (GAA) nucleotide repeat expansions in the first intron of the …

Friedreich's ataxia (FRDA; OMIM 229300), an autosomal recessive neurodegenerative
mitochondrial disease, is the most prevalent hereditary ataxia. In addition, FRDA patients …

Background/Aims: Cardiac fibrosis is a major cause of diverse cardiovascular diseases.
MicroRNAs have recently been proven a novel class of regulators of cardiac fibrosis. In this …

Altered autophagy is a hallmark of neurodegeneration but how autophagy is regulated in the
brain and dysfunctional autophagy leads to neuronal death has remained cryptic. Being a …

Friedreich's ataxia is the commonest autosomal recessive ataxia among population of
European descent. Despite the huge advances performed in the last decades, a cure still …

Background Esophageal squamous cell carcinoma (ESCC) has unfavorable outcomes with
the highest incidence seen in China. Accordingly, exploring effective molecular biomarkers …