In vivo range verification in particle therapy

K Parodi, JC Polf - Medical physics, 2018 - Wiley Online Library
Exploitation of the full potential offered by ion beams in clinical practice is still hampered by
several sources of treatment uncertainties, particularly related to the limitations of our ability …

[HTML][HTML] The role of Monte Carlo simulation in understanding the performance of proton computed tomography

G Dedes, J Dickmann, V Giacometti, S Rit… - … für Medizinische Physik, 2022 - Elsevier
Proton computed tomography (pCT) is a promising tomographic imaging modality allowing
direct reconstruction of proton relative stop** power (RSP) required for proton therapy …

Dosimetric accuracy and radiobiological implications of ion computed tomography for proton therapy treatment planning

S Meyer, F Kamp, T Tessonnier, A Mairani… - Physics in Medicine …, 2019 - iopscience.iop.org
Ion computed tomography (iCT) represents a potential replacement for x-ray CT (xCT) in ion
therapy treatment planning to reduce range uncertainties, inherent in the semi-empirical …

Assessment of range uncertainty in lung-like tissue using a porcine lung phantom and proton radiography

A Meijers, OC Seller, J Free… - Physics in Medicine …, 2020 - iopscience.iop.org
Thoracic tumours are increasingly considered indications for pencil beam scanned proton
therapy (PBS-PT) treatments. Conservative robustness settings have been suggested due to …

Proof of principle of helium‐beam radiography using silicon pixel detectors for energy deposition measurement, identification, and tracking of single ions

T Gehrke, R Gallas, O Jäkel, M Martišíková - Medical physics, 2018 - Wiley Online Library
Purpose Hadron therapy has the capability to provide a high dose conformation to tumor
regions. However, it requires an accurate target positioning. Thus, the precise monitoring of …

Theoretical and experimental comparison of proton and helium-beam radiography using silicon pixel detectors

T Gehrke, C Amato, S Berke… - Physics in Medicine & …, 2018 - iopscience.iop.org
Ion-beam radiography (iR ad) could potentially improve the quality control of ion-beam
therapy. The main advantage of iR ad is the possibility to directly measure the integrated …

Prediction of image noise contributions in proton computed tomography and comparison to measurements

J Dickmann, P Wesp, M Rädler, S Rit… - Physics in Medicine …, 2019 - iopscience.iop.org
We present a method to accurately predict image noise in proton computed tomography
(pCT) using data generated from a Monte Carlo simulation and a patient or object model that …

Two-dimensional noise reconstruction in proton computed tomography using distance-driven filtered back-projection of simulated projections

M Rädler, G Landry, S Rit, RW Schulte… - Physics in Medicine …, 2018 - iopscience.iop.org
We present a formalism for two-dimensional (2D) noise reconstruction in proton computed
tomography (pCT). This is necessary for the application of fluence modulated pCT (FMpCT) …

Experimental fluence‐modulated proton computed tomography by pencil beam scanning

G Dedes, RP Johnson, M Pankuch, N Detrich… - Medical …, 2018 - Wiley Online Library
Purpose This experimental study is aimed at demonstrating, using a simple cylindrical water
phantom, the feasibility of fluence‐modulated proton computed tomography (FMpCT) by …

Patient-specific CT calibration based on ion radiography for different detector configurations in 1H, 4He and 12C ion pencil beam scanning

C Gianoli, M Göppel, S Meyer… - Physics in Medicine …, 2020 - iopscience.iop.org
The empirical conversion of the treatment planning x-ray computed tomography (CT) image
to ion stop** power relative to water causes dose calculation inaccuracies in ion beam …