The blood-testis barrier (BTB) is one of the tightest blood-tissue barriers in the mammalian
body. It divides the seminiferous epithelium into the basal and the apical (adluminal) …

BACKGROUND In recent decades, a broad range of strategies have been applied to model
the testicular microenvironment in vitro. These models have been utilized to study testicular …

Awareness of risks posed by widespread presence of nanoplastics (NPs) and bioavailability
and potential to interact with organic pollutants has been increasing. Inhalation is one of the …

Background The testicular organoid concept has recently been introduced in tissue
engineering to refer to testicular cell organizations modeling testicular architecture and …

The growing global deterioration in several aspects of human health has been partly
attributed to hazardous effects of endocrine-disrupting chemicals (EDCs) exposure …

Pressure towards population aging in the demographic pyramid is not only due to
sociological/personal choices but also due to subfertility or infertility. There are several …

The creation of a testis organoid (artificial testis tissue) with sufficient resemblance to the
complex form and function of the innate testis remains challenging, especially using non …

In the pharmaceutical industry, preclinical developmental and reproductive toxicity studies
are conducted in laboratory animals in order to predict and prevent adverse effects of drugs …

Bisphenol A (BPA), an endocrine-disrupting compound, was found to be a testicular toxicant
in animal models. Bisphenol S (BPS), bisphenol AF (BPAF), and tetrabromobisphenol A …

Sertoli cells isolated from rodents or humans and cultured in vitro are known to establish a
functional tight junction (TJ)-permeability barrier that mimics the blood–testis barrier (BTB) in …