Spreading depression (SD) is a transient wave of near-complete neuronal and glial
depolarization associated with massive transmembrane ionic and water shifts. It is …

Punctuated episodes of spreading depolarizations erupt in the brain, encumbering tissue
structure and function, and raising fascinating unanswered questions concerning their …

The term spreading depolarization (SD) refers to waves of abrupt, sustained mass
depolarization in gray matter of the CNS. SD, which spreads from neuron to neuron in …

Spreading depression (SD) and the related hypoxic SD-like depolarization (HSD) are
characterized by rapid and nearly complete depolarization of a sizable population of brain …

Background When a patient arrives in the emergency department following a stroke, a
traumatic brain injury, or sudden cardiac arrest, there is no therapeutic drug available to help …

Headache attacks and autonomic dysfunctions characterize migraine, a very common,
disabling disorder with a prevalence of 12% in the general population of Western countries …

Spreading depolarization of cells in cerebral grey matter is characterized by massive ion
translocation, neuronal swelling and large changes in direct current-coupled voltage …

Neuronal cytotoxic edema is the morphological correlate of the near-complete neuronal
battery breakdown called spreading depolarization, or conversely, spreading depolarization …

Spreading depression (SD), a transient reversible phenomenon with characteristic ionic,
metabolic and hemodynamic changes, has been known for over 55 years. A vast number of …

Epilepsy is a common neurological disease but the mechanism of seizure generation has
been only partially unraveled. Furthermore, almost 30% of epileptic patients are resistant to …