Neurodegenerative disorders have a common characteristic that is the involvement of
different cell types, typically the reactivity of astrocytes and microglia, characterizing gliosis …

Since the emergence of Zika virus (ZIKV), reports of microcephaly have increased
considerably in Brazil; however, causality between the viral epidemic and malformations in …

Amburana cearensis AC Smith is an endemic tree from Northeastern Brazil used in folk
medicine as teas, decocts and syrups for the treatment of various respiratory and …

Schizophrenia has been defined as a neurodevelopmental disease that causes changes in
the process of thoughts, perceptions, and emotions, usually leading to a mental deterioration …

Background Agathisflavone, a biflavonoid isolated from Schinus polygamus (Cav.) Cabrera
leaves been reported to promote various biological activities such as anti-inflammatory …

Purpose Free radicals are considered as the causative agents of a variety of acute and
chronic pathologies. Natural antioxidants have drawn attention of the researchers in recent …

Flavonoids are bioactive compounds that are known to be neuroprotective against
glutamate-mediated excitotoxicity, one of the major causes of neurodegeneration. The …

Flavonoids target a variety of pathophysiological mechanisms and are therefore increasingly
considered as compounds encompassed with therapeutic potentials in diseases such as …

Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have extensive self-
renewal capacity and the potential to differentiate into all tissue-specific cell lineages …

Background: Reactive astrogliosis and microgliosis are coordinated responses to CNS
insults and are pathological hallmarks of traumatic brain injury (TBI). In these conditions …